Role of β2-integrins for homing and neovascularization capacity of endothelial progenitor cells
The mechanisms of homing of endothelial progenitor cells (EPCs) to sites of ischemia are unclear. Here, we demonstrate that ex vivo–expanded EPCs as well as murine hematopoietic Sca-1+/Lin− progenitor cells express β2-integrins, which mediate the adhesion of EPCs to endothelial cell monolayers and t...
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| Veröffentlicht in: | The Journal of experimental medicine 2005-01, Vol.201 (1), p.63-72 |
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| container_title | The Journal of experimental medicine |
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| creator | Chavakis, Emmanouil Aicher, Alexandra Heeschen, Christopher Sasaki, Ken-ichiro Kaiser, Ralf El Makhfi, Naual Urbich, Carmen Peters, Thorsten Scharffetter-Kochanek, Karin Zeiher, Andreas M. Chavakis, Triantafyllos Dimmeler, Stefanie |
| description | The mechanisms of homing of endothelial progenitor cells (EPCs) to sites of ischemia are unclear. Here, we demonstrate that ex vivo–expanded EPCs as well as murine hematopoietic Sca-1+/Lin− progenitor cells express β2-integrins, which mediate the adhesion of EPCs to endothelial cell monolayers and their chemokine-induced transendothelial migration in vitro. In a murine model of hind limb ischemia, Sca-1+/Lin− hematopoietic progenitor cells from β2-integrin–deficient mice are less capable of homing to sites of ischemia and of improving neovascularization. Preactivation of the β2-integrins expressed on EPCs by activating antibodies augments the EPC-induced neovascularization in vivo. These results provide evidence for a novel function of β2-integrins in postnatal vasculogenesis. |
| doi_str_mv | 10.1084/jem.20041402 |
| format | Article |
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| title | Role of β2-integrins for homing and neovascularization capacity of endothelial progenitor cells |
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