Identification of functional human splenic memory B cells by expression of CD148 and CD27

Memory B cells isolated from human tonsils are characterized by an activated cell surface phenotype, localization to mucosal epithelium, expression of somatically mutated immunoglobulin (Ig) variable (V) region genes, and a preferential differentiation into plasma cells in vitro. In spleens of both...

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Veröffentlicht in:	The Journal of experimental medicine 1998-11, Vol.188 (9), p.1691-1703
Hauptverfasser:	Tangye, S G, Liu, Y J, Aversa, G, Phillips, J H, de Vries, J E
Format:	Artikel
Sprache:	eng
Schlagworte:	B-Lymphocyte Subsets - cytology B-Lymphocyte Subsets - enzymology B-Lymphocyte Subsets - immunology B-Lymphocytes - cytology B-Lymphocytes - enzymology B-Lymphocytes - immunology Base Sequence Biomarkers Cell Differentiation DNA Primers - genetics Genes, Immunoglobulin Humans Immunoglobulin Variable Region - genetics Immunologic Memory Molecular Sequence Data Mutation Phenotype Polymerase Chain Reaction Protein Tyrosine Phosphatases - immunology Receptor-Like Protein Tyrosine Phosphatases, Class 3 Sequence Homology, Nucleic Acid Spleen - cytology Spleen - immunology Tumor Necrosis Factor Receptor Superfamily, Member 7 - metabolism
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