Interleukin 12-mediated prevention of spontaneous mammary adenocarcinomas in two lines of Her-2/neu transgenic mice

The ability of interleukin (IL)-12 to prevent tumors when administered to individuals with a genetic risk of cancer was studied in two lines of transgenic mice expressing rat HER-2/neu oncogene in the mammary gland. Female BALB/c (H-2(d)) mice carrying the activated HER-2/ neu oncogene show no morph...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of experimental medicine 1998-08, Vol.188 (3), p.589-596
Hauptverfasser:	Boggio, K, Nicoletti, G, Di Carlo, E, Cavallo, F, Landuzzi, L, Melani, C, Giovarelli, M, Rossi, I, Nanni, P, De Giovanni, C, Bouchard, P, Wolf, S, Modesti, A, Musiani, P, Lollini, P L, Colombo, M P, Forni, G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - immunology Antineoplastic Agents - pharmacology Carcinoma in Situ - genetics Carcinoma in Situ - immunology Carcinoma in Situ - prevention & control Carcinoma, Lobular - genetics Carcinoma, Lobular - immunology Carcinoma, Lobular - prevention & control CD4-Positive T-Lymphocytes - cytology CD8-Positive T-Lymphocytes - cytology CD8-Positive T-Lymphocytes - immunology Chemokine CXCL10 Chemokine CXCL9 Chemokines, CXC - genetics Female Interferon-gamma - immunology Interleukin-12 - immunology Interleukin-12 - pharmacology Lymphocyte Depletion Male Mammary Neoplasms, Experimental - immunology Mammary Neoplasms, Experimental - prevention & control Mice Mice, Inbred BALB C Mice, Transgenic Nitric Oxide Synthase - biosynthesis Nitric Oxide Synthase Type II Rats Receptor, ErbB-2 - genetics Receptor, ErbB-2 - physiology Tumor Necrosis Factor-alpha - immunology Vascular Cell Adhesion Molecule-1 - biosynthesis
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!