Molecular cloning of the cDNA encoding pp36, a tyrosine-phosphorylated adaptor protein selectively expressed by T cells and natural killer cells

Activation of T and natural killer (NK) cells leads to the tyrosine phosphorylation of pp36 and to its association with several signaling molecules, including phospholipase Cgamma-1 and Grb2. Microsequencing of peptides derived from purified rat pp36 protein led to the cloning, in rat and man, of cD...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of experimental medicine 1998-04, Vol.187 (7), p.1157-1161
Hauptverfasser:	Weber, J R, Orstavik, S, Torgersen, K M, Danbolt, N C, Berg, S F, Ryan, J C, Taskén, K, Imboden, J B, Vaage, J T
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing Amino Acid Sequence Animals Brief Definitive Report Cells, Cultured Cloning, Molecular Deoxyuridine - analogs & derivatives Deoxyuridine - chemistry GRB2 Adaptor Protein Humans Isoenzymes - metabolism Killer Cells, Natural - immunology Molecular Sequence Data Peptide Fragments - immunology Phospholipase C gamma Phosphoproteins - chemistry Propanolamines - chemistry Proteins - metabolism Rats Recombinant Proteins - immunology RNA, Messenger - metabolism Sequence Analysis, DNA src Homology Domains - genetics T-Lymphocytes - immunology Thymus Gland - physiology Type C Phospholipases - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!