Role of Dok-1 and Dok-2 in leukemia suppression

Chronic myelogenous leukemia (CML) is characterized by the presence of the chimeric p210bcr/abl oncoprotein that shows elevated and constitutive protein tyrosine kinase activity relative to the normal c-abl tyrosine kinase. Although several p210bcr/abl substrates have been identified, their relevanc...

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Veröffentlicht in:	The Journal of experimental medicine 2004-12, Vol.200 (12), p.1689-1695
Hauptverfasser:	Niki, Masaru, Di Cristofano, Antonio, Zhao, Mingming, Honda, Hiroaki, Hirai, Hisamaru, Van Aelst, Linda, Cordon-Cardo, Carlos, Pandolfi, Pier Paolo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Animals Apoptosis - genetics Blast Crisis - genetics Blast Crisis - metabolism Blast Crisis - pathology Bone Marrow - metabolism Bone Marrow - pathology Brief Definitive Report Cell Proliferation DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Fusion Proteins, bcr-abl - genetics Fusion Proteins, bcr-abl - metabolism Gene Expression Regulation, Leukemic - genetics Hematopoiesis - genetics Homeostasis - genetics Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics Leukemia, Myelogenous, Chronic, BCR-ABL Positive - metabolism Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology MAP Kinase Signaling System - genetics Mice Mice, Knockout Mitogen-Activated Protein Kinase 1 - metabolism p120 GTPase Activating Protein - metabolism Phosphoproteins - genetics Phosphoproteins - metabolism Phosphorylation RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism
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