Structural basis for the restoration of TCR recognition of an MHC allelic variant by peptide secondary anchor substitution

Major histocompatibility complex (MHC) class I variants H-2K(b) and H-2K(bm8) differ primarily in the B pocket of the peptide-binding groove, which serves to sequester the P2 secondary anchor residue. This polymorphism determines resistance to lethal herpes simplex virus (HSV-1) infection by modulat...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	The Journal of experimental medicine 2004-12, Vol.200 (11), p.1445-1454
Hauptverfasser:	Miley, Michael J, Messaoudi, Ilhem, Metzner, Beatrix M, Wu, Yudong, Nikolich-Zugich, Janko, Fremont, Daved H
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Animals Circular Dichroism Crystallography, X-Ray H-2 Antigens - chemistry Herpes simplex virus 1 Hydrogen Bonding Immunodominant Epitopes Protein Conformation Receptors, Antigen, T-Cell - chemistry T-Lymphocytes - immunology Viral Envelope Proteins - immunology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!