Thymic T cell development and progenitor localization depend on CCR7

T cell differentiation in the adult thymus depends on sequential interactions between lymphoid progenitors and stromal cells found in distinct regions of the cortex and medulla. Therefore, migration of T cell progenitors through distinct stromal environments seems to be a crucial process regulating...

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Veröffentlicht in:	The Journal of experimental medicine 2004-08, Vol.200 (4), p.481-491
Hauptverfasser:	Misslitz, Ana, Pabst, Oliver, Hintzen, Gabriele, Ohl, Lars, Kremmer, Elisabeth, Petrie, Howard T, Förster, Reinhold
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Differentiation - physiology Cell Movement - physiology Flow Cytometry Immunohistochemistry Mice Mice, Inbred C57BL Models, Biological Receptors, CCR7 Receptors, Chemokine - metabolism Receptors, Chemokine - physiology Signal Transduction - physiology Stromal Cells - physiology T-Lymphocytes - physiology Thymus Gland - physiology
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