Developmental stage, phenotype, and migration distinguish naive- and effector/memory-like CD4+ regulatory T cells
Regulatory T cells (Tregs) fulfill a central role in immune regulation. We reported previously that the integrin alphaEbeta7 discriminates distinct subsets of murine CD4+ regulatory T cells. Use of this marker has now helped to unravel a fundamental dichotomy among regulatory T cells. alphaE-CD25+ c...
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| Veröffentlicht in: | The Journal of experimental medicine 2004-02, Vol.199 (3), p.303-313 |
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| container_title | The Journal of experimental medicine |
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| creator | Huehn, Jochen Siegmund, Kerstin Lehmann, Joachim C U Siewert, Christiane Haubold, Uta Feuerer, Markus Debes, Gudrun F Lauber, Joerg Frey, Oliver Przybylski, Grzegorz K Niesner, Uwe de la Rosa, Maurus Schmidt, Christian A Bräuer, Rolf Buer, Jan Scheffold, Alexander Hamann, Alf |
| description | Regulatory T cells (Tregs) fulfill a central role in immune regulation. We reported previously that the integrin alphaEbeta7 discriminates distinct subsets of murine CD4+ regulatory T cells. Use of this marker has now helped to unravel a fundamental dichotomy among regulatory T cells. alphaE-CD25+ cells expressed L-selectin and CCR7, enabling recirculation through lymphoid tissues. In contrast, alphaE -positive subsets (CD25+ and CD25-) displayed an effector/memory phenotype expressing high levels of E/P-selectin-binding ligands, multiple adhesion molecules as well as receptors for inflammatory chemokines, allowing efficient migration into inflamed sites. Accordingly, alphaE -expressing cells were found to be the most potent suppressors of inflammatory processes in disease models such as antigen-induced arthritis. |
| doi_str_mv | 10.1084/jem.20031562 |
| format | Article |
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We reported previously that the integrin alphaEbeta7 discriminates distinct subsets of murine CD4+ regulatory T cells. Use of this marker has now helped to unravel a fundamental dichotomy among regulatory T cells. alphaE-CD25+ cells expressed L-selectin and CCR7, enabling recirculation through lymphoid tissues. In contrast, alphaE -positive subsets (CD25+ and CD25-) displayed an effector/memory phenotype expressing high levels of E/P-selectin-binding ligands, multiple adhesion molecules as well as receptors for inflammatory chemokines, allowing efficient migration into inflamed sites. Accordingly, alphaE -expressing cells were found to be the most potent suppressors of inflammatory processes in disease models such as antigen-induced arthritis.</description><identifier>ISSN: 0022-1007</identifier><identifier>EISSN: 1540-9538</identifier><identifier>DOI: 10.1084/jem.20031562</identifier><identifier>PMID: 14757740</identifier><language>eng</language><publisher>United States: The Rockefeller University Press</publisher><subject>Animals ; Arthritis, Experimental - immunology ; CD4 Antigens - immunology ; CD4-Positive T-Lymphocytes - immunology ; Immunologic Memory - immunology ; Immunophenotyping ; Inflammation - immunology ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Oligonucleotide Array Sequence Analysis ; Receptors, Interleukin-2 - immunology ; Reverse Transcriptase Polymerase Chain Reaction ; T-Lymphocyte Subsets - immunology</subject><ispartof>The Journal of experimental medicine, 2004-02, Vol.199 (3), p.303-313</ispartof><rights>Copyright © 2004, The Rockefeller University Press</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c382t-2a1641b4cff40b0e2e6f98b89ee77982779ff040e7dd22abbb914f2654c0a1c63</citedby><cites>FETCH-LOGICAL-c382t-2a1641b4cff40b0e2e6f98b89ee77982779ff040e7dd22abbb914f2654c0a1c63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14757740$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Huehn, Jochen</creatorcontrib><creatorcontrib>Siegmund, Kerstin</creatorcontrib><creatorcontrib>Lehmann, Joachim C U</creatorcontrib><creatorcontrib>Siewert, Christiane</creatorcontrib><creatorcontrib>Haubold, Uta</creatorcontrib><creatorcontrib>Feuerer, Markus</creatorcontrib><creatorcontrib>Debes, Gudrun F</creatorcontrib><creatorcontrib>Lauber, Joerg</creatorcontrib><creatorcontrib>Frey, Oliver</creatorcontrib><creatorcontrib>Przybylski, Grzegorz K</creatorcontrib><creatorcontrib>Niesner, Uwe</creatorcontrib><creatorcontrib>de la Rosa, Maurus</creatorcontrib><creatorcontrib>Schmidt, Christian A</creatorcontrib><creatorcontrib>Bräuer, Rolf</creatorcontrib><creatorcontrib>Buer, Jan</creatorcontrib><creatorcontrib>Scheffold, Alexander</creatorcontrib><creatorcontrib>Hamann, Alf</creatorcontrib><title>Developmental stage, phenotype, and migration distinguish naive- and effector/memory-like CD4+ regulatory T cells</title><title>The Journal of experimental medicine</title><addtitle>J Exp Med</addtitle><description>Regulatory T cells (Tregs) fulfill a central role in immune regulation. We reported previously that the integrin alphaEbeta7 discriminates distinct subsets of murine CD4+ regulatory T cells. Use of this marker has now helped to unravel a fundamental dichotomy among regulatory T cells. alphaE-CD25+ cells expressed L-selectin and CCR7, enabling recirculation through lymphoid tissues. In contrast, alphaE -positive subsets (CD25+ and CD25-) displayed an effector/memory phenotype expressing high levels of E/P-selectin-binding ligands, multiple adhesion molecules as well as receptors for inflammatory chemokines, allowing efficient migration into inflamed sites. Accordingly, alphaE -expressing cells were found to be the most potent suppressors of inflammatory processes in disease models such as antigen-induced arthritis.</description><subject>Animals</subject><subject>Arthritis, Experimental - immunology</subject><subject>CD4 Antigens - immunology</subject><subject>CD4-Positive T-Lymphocytes - immunology</subject><subject>Immunologic Memory - immunology</subject><subject>Immunophenotyping</subject><subject>Inflammation - immunology</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mice, Inbred C57BL</subject><subject>Oligonucleotide Array Sequence Analysis</subject><subject>Receptors, Interleukin-2 - immunology</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>T-Lymphocyte Subsets - immunology</subject><issn>0022-1007</issn><issn>1540-9538</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkTlPxDAQhS0EguXoqJErGgiMHedqkNBySkg0UFtOMs4akjjYyUr77zGwXM3MSPPpzfEIOWRwxiAX5y_YnXGAmCUp3yAzlgiIiiTON8kMgPOIAWQ7ZNf7FwAmRJJukx0msiTLBMzI2xUusbVDh_2oWupH1eApHRbY23E1hFL1Ne1M49RobE9r40fTN5PxC9ors8ToE0CtsRqtO--ws24VteYV6fxKnFCHzdSq0FrRJ1ph2_p9sqVV6_FgnffI88310_wueni8vZ9fPkRVnPMx4oqlgpWi0lpACcgx1UVe5gVilhU5D0FrEIBZXXOuyrIsmNA8TUQFilVpvEcuvnSHqeywrsKBTrVycKZTbiWtMvJ_pzcL2dil5JyxMCEIHK8FnH2b0I-yM_7jBNWjnbzMgcU8vDSAp19g5az3DvXPEAbywyMZPJLfHgX86O9iv_DalPgdXLyPdw</recordid><startdate>20040202</startdate><enddate>20040202</enddate><creator>Huehn, Jochen</creator><creator>Siegmund, Kerstin</creator><creator>Lehmann, Joachim C U</creator><creator>Siewert, Christiane</creator><creator>Haubold, Uta</creator><creator>Feuerer, Markus</creator><creator>Debes, Gudrun F</creator><creator>Lauber, Joerg</creator><creator>Frey, Oliver</creator><creator>Przybylski, Grzegorz K</creator><creator>Niesner, Uwe</creator><creator>de la Rosa, Maurus</creator><creator>Schmidt, Christian A</creator><creator>Bräuer, Rolf</creator><creator>Buer, Jan</creator><creator>Scheffold, Alexander</creator><creator>Hamann, Alf</creator><general>The Rockefeller University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20040202</creationdate><title>Developmental stage, phenotype, and migration distinguish naive- and effector/memory-like CD4+ regulatory T cells</title><author>Huehn, Jochen ; Siegmund, Kerstin ; Lehmann, Joachim C U ; Siewert, Christiane ; Haubold, Uta ; Feuerer, Markus ; Debes, Gudrun F ; Lauber, Joerg ; Frey, Oliver ; Przybylski, Grzegorz K ; Niesner, Uwe ; de la Rosa, Maurus ; Schmidt, Christian A ; Bräuer, Rolf ; Buer, Jan ; Scheffold, Alexander ; Hamann, Alf</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c382t-2a1641b4cff40b0e2e6f98b89ee77982779ff040e7dd22abbb914f2654c0a1c63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Animals</topic><topic>Arthritis, Experimental - immunology</topic><topic>CD4 Antigens - immunology</topic><topic>CD4-Positive T-Lymphocytes - immunology</topic><topic>Immunologic Memory - immunology</topic><topic>Immunophenotyping</topic><topic>Inflammation - immunology</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Mice, Inbred C57BL</topic><topic>Oligonucleotide Array Sequence Analysis</topic><topic>Receptors, Interleukin-2 - immunology</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>T-Lymphocyte Subsets - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Huehn, Jochen</creatorcontrib><creatorcontrib>Siegmund, Kerstin</creatorcontrib><creatorcontrib>Lehmann, Joachim C U</creatorcontrib><creatorcontrib>Siewert, Christiane</creatorcontrib><creatorcontrib>Haubold, Uta</creatorcontrib><creatorcontrib>Feuerer, Markus</creatorcontrib><creatorcontrib>Debes, Gudrun F</creatorcontrib><creatorcontrib>Lauber, Joerg</creatorcontrib><creatorcontrib>Frey, Oliver</creatorcontrib><creatorcontrib>Przybylski, Grzegorz K</creatorcontrib><creatorcontrib>Niesner, Uwe</creatorcontrib><creatorcontrib>de la Rosa, Maurus</creatorcontrib><creatorcontrib>Schmidt, Christian A</creatorcontrib><creatorcontrib>Bräuer, Rolf</creatorcontrib><creatorcontrib>Buer, Jan</creatorcontrib><creatorcontrib>Scheffold, Alexander</creatorcontrib><creatorcontrib>Hamann, Alf</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of experimental medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Huehn, Jochen</au><au>Siegmund, Kerstin</au><au>Lehmann, Joachim C U</au><au>Siewert, Christiane</au><au>Haubold, Uta</au><au>Feuerer, Markus</au><au>Debes, Gudrun F</au><au>Lauber, Joerg</au><au>Frey, Oliver</au><au>Przybylski, Grzegorz K</au><au>Niesner, Uwe</au><au>de la Rosa, Maurus</au><au>Schmidt, Christian A</au><au>Bräuer, Rolf</au><au>Buer, Jan</au><au>Scheffold, Alexander</au><au>Hamann, Alf</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Developmental stage, phenotype, and migration distinguish naive- and effector/memory-like CD4+ regulatory T cells</atitle><jtitle>The Journal of experimental medicine</jtitle><addtitle>J Exp Med</addtitle><date>2004-02-02</date><risdate>2004</risdate><volume>199</volume><issue>3</issue><spage>303</spage><epage>313</epage><pages>303-313</pages><issn>0022-1007</issn><eissn>1540-9538</eissn><abstract>Regulatory T cells (Tregs) fulfill a central role in immune regulation. 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| ispartof | The Journal of experimental medicine, 2004-02, Vol.199 (3), p.303-313 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animals Arthritis, Experimental - immunology CD4 Antigens - immunology CD4-Positive T-Lymphocytes - immunology Immunologic Memory - immunology Immunophenotyping Inflammation - immunology Mice Mice, Inbred BALB C Mice, Inbred C57BL Oligonucleotide Array Sequence Analysis Receptors, Interleukin-2 - immunology Reverse Transcriptase Polymerase Chain Reaction T-Lymphocyte Subsets - immunology |
| title | Developmental stage, phenotype, and migration distinguish naive- and effector/memory-like CD4+ regulatory T cells |
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