Lentiviral RNAi-induced downregulation of adenosine kinase in human mesenchymal stem cell grafts: A novel perspective for seizure control

Cell therapies based on focal delivery of the inhibitory neuromodulator adenosine were previously shown to provide potent seizure suppression in animal models of epilepsy. However, hitherto used therapeutic cells were derived from rodents and thus not suitable for clinical applications. Autologous p...

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Veröffentlicht in:	Experimental neurology 2007-11, Vol.208 (1), p.26-37
Hauptverfasser:	Ren, Gaoying, Li, Tianfu, Lan, Jiang Quan, Wilz, Andrew, Simon, Roger P., Boison, Detlev
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Adenosine - metabolism Adenosine kinase Adenosine Kinase - genetics Adenosine Kinase - metabolism Animals Biological and medical sciences Cell therapy Down-Regulation Epilepsy Excitatory Amino Acid Agonists Genetic Vectors Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Hippocampus - pathology Hippocampus - physiopathology Human mesenchymal stem cells Humans Kainic Acid Lentivirus Lentivirus - genetics Male Medical sciences Mesenchymal Stem Cell Transplantation Mesenchymal Stromal Cells - enzymology Mesenchymal Stromal Cells - metabolism Mice Mice, Inbred C57BL Nervous system (semeiology, syndromes) Neurology Neuroprotection RNA Interference RNAi Status epilepticus Status Epilepticus - chemically induced Status Epilepticus - pathology Status Epilepticus - physiopathology Status Epilepticus - surgery Transduction, Genetic
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