Thrombin-thrombomodulin connects coagulation and fibrinolysis: more than an in vitro phenomenon

Thrombin activatable fibrinolysis inhibitor (TAFI), when activated, forms a basic carboxypeptidase that can inhibit fibrinolysis. Potential physiologic activators include both thrombin and plasmin. In vitro, thrombomodulin and glycosaminoglycans increase the catalytic efficiency of TAFI activation b...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Blood 2007-11, Vol.110 (9), p.3168-3175
Hauptverfasser:	Binette, Tanya M., Taylor, Fletcher B., Peer, Glenn, Bajzar, Laszlo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - pharmacology Biological and medical sciences Blood Coagulation - physiology Carboxypeptidase B2 - antagonists & inhibitors Carboxypeptidase B2 - blood Carboxypeptidase B2 - immunology Carboxypeptidase B2 - metabolism Escherichia coli Infections - blood Escherichia coli Infections - pathology Fibrin Fibrinogen Degradation Products - metabolism Fibrinogen - metabolism Fibrinolysis - physiology Half-Life Hematologic and hematopoietic diseases Hemostasis, Thrombosis, and Vascular Biology Humans Medical sciences Microbial Sensitivity Tests Papio cynocephalus Sepsis - blood Sepsis - pathology Thrombin - physiology Thrombomodulin - physiology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!