$Phase 1 trial and pharmacokinetic study of arsenic trioxide in children and adolescents with refractory or relapsed acute leukemia, including acute promyelocytic leukemia or lymphoma$

Phase 1 trial and pharmacokinetic study of arsenic trioxide in children and adolescents with refractory or relapsed acute leukemia, including acute promyelocytic leukemia or lymphoma

Arsenic trioxide (ATO) induces remission in 85% of adults with refractory acute promyelocytic leukemia (APL). We conducted a phase 1 trial of ATO in children (median age 13 y, range, 2-19) with refractory leukemia. ATO was administered intravenously over 2 hours, 5 d/wk for 20 doses/cycle. Patients...

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Veröffentlicht in:	Blood 2008-01, Vol.111 (2), p.566-573
Hauptverfasser:	Fox, Elizabeth, Razzouk, Bassem I., Widemann, Brigitte C., Xiao, Shaun, O'Brien, Michelle, Goodspeed, Wendy, Reaman, Gregory H., Blaney, Susan M., Murgo, Anthony J., Balis, Frank M., Adamson, Peter C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Abdominal Pain - chemically induced Abdominal Pain - drug therapy Adolescent Adult Antineoplastic Agents - adverse effects Antineoplastic Agents - pharmacokinetics Arsenic Trioxide Arsenicals - adverse effects Arsenicals - pharmacokinetics Biological and medical sciences Child Child, Preschool Clinical Trials and Observations Constipation - chemically induced Constipation - drug therapy Dermatitis - drug therapy Dermatitis - etiology Dose-Response Relationship, Drug Female Headache - chemically induced Headache - drug therapy Hematologic and hematopoietic diseases Humans Hyperglycemia - chemically induced Hyperglycemia - drug therapy Infusions, Intravenous Leukemia, Promyelocytic, Acute - complications Leukemia, Promyelocytic, Acute - drug therapy Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphoma - complications Lymphoma - drug therapy Male Medical sciences Nausea - chemically induced Nausea - drug therapy Oxides - adverse effects Oxides - pharmacokinetics Pancreatitis - chemically induced Pancreatitis - drug therapy Pneumonia - chemically induced Pneumonia - drug therapy Recurrence Time Factors Vomiting - chemically induced Vomiting - drug therapy Water-Electrolyte Balance - drug effects
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