Evaluation of fatty acid amides in the carrageenan-induced paw edema model

While it has long been recognized that Δ9-tetrahydrocannabinol (THC), the primary psychoactive constituent of cannabis, and other cannabinoid receptor agonists possess anti-inflammatory properties, their well known CNS effects have dampened enthusiasm for therapeutic development. On the other hand,...

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Veröffentlicht in:	Neuropharmacology 2008-01, Vol.54 (1), p.181-188
Hauptverfasser:	Wise, Laura E., Cannavacciulo, Roberta, Cravatt, Benjamin F., Martin, Billy F., Lichtman, Aron H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amidohydrolases - deficiency Analysis of Variance Animals Arachidonic Acids - metabolism Cannabinoids - metabolism Carrageenan Dexamethasone - therapeutic use Disease Models, Animal Dose-Response Relationship, Drug Dronabinol - therapeutic use Drug Interactions Edema Edema - chemically induced Edema - drug therapy Edema - genetics Edema - metabolism Endocannabinoids Endogenous cannabinoid Ethanolamines - metabolism Fatty acid amide hydrolase (FAAH) Female Inflammation Male Mice Mice, Inbred C57BL Mice, Knockout N-Arachidonoyl ethanolamine (anandamide) N-Palmitoyl ethanolamine (PEA) Oleic Acids - metabolism Polyunsaturated Alkamides - metabolism THC
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