IL‐12 stimulation but not B7 expression increases melanoma killing by patient cytotoxic T lymphocytes (CTL)

Recent studies have demonstrated that rodent tumour cells engineered to secrete a variety of cytokines, or to express foreign antigens, MHC molecules or co‐stimulatory molecules, are rejected by syngeneic animals. These observations have led to the initiation of a number of clinical trials using gen...

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Veröffentlicht in:	Clinical and experimental immunology 1996-08, Vol.105 (2), p.353-359
Hauptverfasser:	DE WIT, D., FLEMMING, C. L., HARRIS, J. D., PALMER, K. J., MOORE, J. S., GORE, M. E., COLLINS, M. K. L.
Format:	Artikel
Sprache:	eng
Schlagworte:	B7-1 Antigen - physiology Biological and medical sciences cytotoxic T cell Cytotoxicity, Immunologic Host-tumor relations. Immunology. Biological markers Humans IL‐12 Interleukin-12 - pharmacology Medical sciences melanoma Melanoma - immunology Original T-Lymphocytes, Cytotoxic - immunology Tumor Cells, Cultured Tumors
Online-Zugang:	Volltext
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