The I Domain Is a Major Recognition Site on the Leukocyte Integrin Mac-1 (CD11b/CD18) for Four Distinct Adhesion Ligands

Despite the identification and characterization of several distinct ligands for the leukocyte integrin (CD11/CD18) family of adhesion receptors, little is known about the structural regions on these molecules that mediate ligand recognition. In this report, we use α subunit chimeras of Mac-1 (CD11b/...

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Veröffentlicht in:	The Journal of cell biology 1993-02, Vol.120 (4), p.1031-1043
Hauptverfasser:	Diamond, Michael S., Garcia-Aguilar, Julio, Bickford, Joanna K., Corbi, Angel L., Springer, Timothy A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal - immunology Antigens, CD - metabolism Binding Sites Biological and medical sciences CD18 Antigens Cell Adhesion Molecules - metabolism Cellular biology Chimeras CHO cells COS cells Divalent cations Epitopes Erythrocytes Fundamental and applied biological sciences. Psychology Humans Integrin alphaXbeta2 - immunology Integrin alphaXbeta2 - metabolism Integrin alphaXbeta2 - ultrastructure Integrins Intercellular Adhesion Molecule-1 Leukocytes Ligands Macrophage-1 Antigen - immunology Macrophage-1 Antigen - metabolism Macrophage-1 Antigen - ultrastructure Molecules Neutrophils Receptors Recombinant Fusion Proteins - immunology Recombinant Fusion Proteins - metabolism Transfection Vertebrates: blood, hematopoietic organs, reticuloendothelial system
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