Aurora-A Kinase Is Required for Centrosome Maturation in Caenorhabditis elegans

Centrosomes mature as cells enter mitosis, accumulating γ-tubulin and other pericentriolar material (PCM) components. This occurs concomitant with an increase in the number of centrosomally organized microtubules (MTs). Here, we use RNA-mediated interference (RNAi) to examine the role of the aurora-...

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Veröffentlicht in:	The Journal of cell biology 2001-12, Vol.155 (7), p.1109-1115
Hauptverfasser:	Hannak, Eva, Kirkham, Matthew, Hyman, Anthony A., Oegema, Karen
Format:	Artikel
Sprache:	eng
Schlagworte:	air-1 gene Animals Antibodies Antibodies - pharmacology Aurora Kinase A Aurora Kinases Aurora-A protein Caenorhabditis elegans Caenorhabditis elegans - physiology Caenorhabditis elegans - ultrastructure Caenorhabditis elegans Proteins Cell cycle Cells Cellular biology Centrosome - drug effects Centrosome - enzymology Centrosome - physiology Centrosomes Embryonic cells Embryos Fluorescence Microscopy, Fluorescence Mitosis Mitotic spindle apparatus Nocodazole - pharmacology Pronucleus Protein-Serine-Threonine Kinases - analysis Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Proteins Recombinant Proteins - analysis Recombinant Proteins - metabolism Tubulin - metabolism Worms
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