Ku70 is required for DNA repair but not for T cell antigen receptor gene recombination In vivo

Ku is a complex of two proteins, Ku70 and Ku80, and functions as a heterodimer to bind DNA double-strand breaks (DSB) and activate DNA-dependent protein kinase. The role of the Ku70 subunit in DNA DSB repair, hypersensitivity to ionizing radiation, and V(D)J recombination was examined in mice that l...

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Veröffentlicht in:	The Journal of experimental medicine 1997-09, Vol.186 (6), p.921-929
Hauptverfasser:	Ouyang, H, Nussenzweig, A, Kurimasa, A, Soares, V C, Li, X, Cordon-Cardo, C, Li, W h, Cheong, N, Nussenzweig, M, Iliakis, G, Chen, D J, Li, G C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Nuclear B-Lymphocytes - cytology B-Lymphocytes - immunology B-Lymphocytes - metabolism Base Sequence BASIC BIOLOGICAL SCIENCES Cell Differentiation DNA - genetics DNA Helicases DNA Primers - genetics DNA Repair - genetics DNA Repair - physiology DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Gene Rearrangement, T-Lymphocyte Gene Targeting Immunology Ku Autoantigen Mice Mice, Knockout Molecular Sequence Data Nuclear Proteins - genetics Nuclear Proteins - metabolism Polymerase Chain Reaction Receptors, Antigen, T-Cell - genetics Recombination, Genetic Research & Experimental Medicine T-Lymphocytes - cytology T-Lymphocytes - immunology T-Lymphocytes - metabolism
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