Interferon gamma (IFN-gamma) is necessary for the genesis of acetylcholine receptor-induced clinical experimental autoimmune myasthenia gravis in mice

Experimental autoimmune myasthenia gravis (EAMG) is an animal model of human myasthenia gravis (MG). In mice, EAMG is induced by immunization with Torpedo californica acetylcholine receptor (AChR) in complete Freund's adjuvant (CFA). However, the role of cytokines in the pathogenesis of EAMG is...

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Veröffentlicht in:	The Journal of experimental medicine 1997-08, Vol.186 (3), p.385-391
Hauptverfasser:	Balasa, B, Deng, C, Lee, J, Bradley, L M, Dalton, D K, Christadoss, P, Sarvetnick, N
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autoantibodies - biosynthesis Autoantibodies - blood Gene Deletion Immunodominant Epitopes - chemistry Immunodominant Epitopes - physiology Immunoglobulin Isotypes - biosynthesis Immunoglobulin Isotypes - blood Interferon-gamma - physiology Lymphocyte Activation - genetics Mice Mice, Inbred C3H Mice, Inbred C57BL Mice, Knockout Myasthenia Gravis - etiology Myasthenia Gravis - genetics Myasthenia Gravis - immunology Receptors, Cholinergic - chemistry Receptors, Cholinergic - immunology Receptors, Cholinergic - physiology
Online-Zugang:	Volltext
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