Cargo of Kinesin Identified as JIP Scaffolding Proteins and Associated Signaling Molecules

The cargo that the molecular motor kinesin moves along microtubules has been elusive. We searched for binding partners of the COOH terminus of kinesin light chain, which contains tetratricopeptide repeat (TPR) motifs. Three proteins were found, the c-jun NH2-terminal kinase (JNK)-interacting protein...

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Veröffentlicht in:	The Journal of cell biology 2001-03, Vol.152 (5), p.959-970
Hauptverfasser:	Verhey, Kristen J., Meyer, Debra, Deehan, Reneé, Blenis, John, Schnapp, Bruce J., Rapoport, Tom A., Margolis, Ben
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing Amino Acid Motifs Amino Acid Sequence Animals Binding Sites Carrier Proteins - chemistry Carrier Proteins - genetics Carrier Proteins - metabolism Cell Line Cells Cellular differentiation COS cells Freight Kinesin - chemistry Kinesin - genetics Kinesin - metabolism LDL-Receptor Related Proteins MAP Kinase Kinase Kinases - metabolism Mice Models, Biological Molecular Motor Proteins - chemistry Molecular Motor Proteins - genetics Molecular Motor Proteins - metabolism Molecular Sequence Data Molecules Mutation Nerve Tissue Proteins - chemistry Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Neurons Neurons - metabolism Original Physiological regulation Plasmids Precipitin Tests Protein Binding Proteins Rats Receptors Receptors, Lipoprotein - metabolism Scaffolds Sequence Alignment Signal Transduction Two-Hybrid System Techniques Yeast
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