Caveolin-2 Is Targeted to Lipid Droplets, a New "Membrane Domain" in the Cell

Caveolin-1 and -2 constitute a framework of caveolae in nonmuscle cells. In the present study, we showed that caveolin-2, especially its β isoform, is targeted to the surface of lipid droplets (LD) by immunofluorescence and immunoelectron microscopy, and by subcellular fractionation. Brefeldin A tre...

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Veröffentlicht in:	The Journal of cell biology 2001-03, Vol.152 (5), p.1079-1085
Hauptverfasser:	Fujimoto, Toyoshi, Kogo, Hiroshi, Ishiguro, Kimiko, Tauchi, Kumi, Nomura, Ryuji
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal cells Animals Antibodies Biological Transport - drug effects Brefeldin A - pharmacology Caveolae Caveolin 1 Caveolin 2 Caveolins Caveolins - chemistry Caveolins - genetics Caveolins - metabolism Cell Line Cell membranes Cells Endoplasmic Reticulum - metabolism Fibroblasts Fluorescent Antibody Technique Humans Lipid Metabolism Lipids Membrane Microdomains - chemistry Membrane Microdomains - metabolism Membranes Mice Microscopy Microscopy, Immunoelectron Organelles - chemistry Organelles - drug effects Organelles - metabolism Organelles - ultrastructure Original P branes Protein isoforms Protein Isoforms - chemistry Protein Isoforms - genetics Protein Isoforms - metabolism Protein Sorting Signals Protein Transport - drug effects Proteins Rats Sequence Deletion - genetics
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