MAFA controls genes implicated in insulin biosynthesis and secretion

Aims/hypothesis Effects of the transcription factor v-maf musculoaponeurotic fibrosarcoma oncogene homologue A (MAFA) on the regulation of beta cell gene expression and function were investigated. Materials and methods INS-1 stable cell lines permitting inducible up- or downregulation of this transc...

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Veröffentlicht in:	Diabetologia 2007-02, Vol.50 (2), p.348-358
Hauptverfasser:	Wang, H, Brun, T, Kataoka, K, Sharma, A. J, Wollheim, C. B
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Beta cells Biological and medical sciences Cell Line, Tumor Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Gene Expression Regulation Humans Insulin - biosynthesis Insulin - genetics Insulin - metabolism Insulin Secretion Insulin-Secreting Cells - metabolism Insulin-Secreting Cells - physiology Insulinoma Islet insulin secretion Lectins, C-Type - deficiency Lectins, C-Type - genetics Lectins, C-Type - physiology MAFA Medical sciences Membrane Glycoproteins - deficiency Membrane Glycoproteins - genetics Membrane Glycoproteins - physiology metabolism Mice Mice, Knockout Pancreatic Neoplasms Rats Transcription, Genetic
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