Local delivery of interleukin 4 by retrovirus-transduced T lymphocytes ameliorates experimental autoimmune encephalomyelitis
Experimental autoimmune encephalomyelitis (EAE) is an inflammatory autoimmune disease of the central nervous system which serves as a model for the human disease multiple sclerosis. We demonstrate here that encephalitogenic T cells, transduced with a retroviral gene, construct to express interleukin...
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| Veröffentlicht in: | The Journal of experimental medicine 1997-05, Vol.185 (9), p.1711-1714 |
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| container_issue | 9 |
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| container_title | The Journal of experimental medicine |
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| creator | Shaw, M K Lorens, J B Dhawan, A DalCanto, R Tse, H Y Tran, A B Bonpane, C Eswaran, S L Brocke, S Sarvetnick, N Steinman, L Nolan, G P Fathman, C G |
| description | Experimental autoimmune encephalomyelitis (EAE) is an inflammatory autoimmune disease of the central nervous system which serves as a model for the human disease multiple sclerosis. We demonstrate here that encephalitogenic T cells, transduced with a retroviral gene, construct to express interleukin 4, and can delay the onset and reduce the severity of EAE when adoptively transferred to myelin basic protein-immunized mice. Thus, T lymphocytes transduced with retroviral vectors can deliver "regulatory cytokines" in a site-specific manner and may represent a viable therapeutic strategy for the treatment of autoimmune disease. |
| doi_str_mv | 10.1084/jem.185.9.1711 |
| format | Article |
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We demonstrate here that encephalitogenic T cells, transduced with a retroviral gene, construct to express interleukin 4, and can delay the onset and reduce the severity of EAE when adoptively transferred to myelin basic protein-immunized mice. Thus, T lymphocytes transduced with retroviral vectors can deliver "regulatory cytokines" in a site-specific manner and may represent a viable therapeutic strategy for the treatment of autoimmune disease.</description><identifier>ISSN: 0022-1007</identifier><identifier>EISSN: 1540-9538</identifier><identifier>DOI: 10.1084/jem.185.9.1711</identifier><identifier>PMID: 9151908</identifier><language>eng</language><publisher>United States: The Rockefeller University Press</publisher><subject>Animals ; Brief Definitive Report ; Encephalomyelitis, Autoimmune, Experimental - therapy ; Genetic Therapy ; Genetic Vectors ; Immunization, Passive ; Immunotherapy ; Interleukin-10 - biosynthesis ; Interleukin-4 - administration & dosage ; Interleukin-4 - biosynthesis ; Mice ; Myelin Basic Protein - immunology ; Receptors, Antigen, T-Cell - metabolism ; Retroviridae - genetics ; T-Lymphocytes ; Transduction, Genetic</subject><ispartof>The Journal of experimental medicine, 1997-05, Vol.185 (9), p.1711-1714</ispartof><rights>1997</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c416t-8ed90434c281e8de328ca8dc078162da01861010e95a3079128b922956ed02023</citedby><cites>FETCH-LOGICAL-c416t-8ed90434c281e8de328ca8dc078162da01861010e95a3079128b922956ed02023</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9151908$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shaw, M K</creatorcontrib><creatorcontrib>Lorens, J B</creatorcontrib><creatorcontrib>Dhawan, A</creatorcontrib><creatorcontrib>DalCanto, R</creatorcontrib><creatorcontrib>Tse, H Y</creatorcontrib><creatorcontrib>Tran, A B</creatorcontrib><creatorcontrib>Bonpane, C</creatorcontrib><creatorcontrib>Eswaran, S L</creatorcontrib><creatorcontrib>Brocke, S</creatorcontrib><creatorcontrib>Sarvetnick, N</creatorcontrib><creatorcontrib>Steinman, L</creatorcontrib><creatorcontrib>Nolan, G P</creatorcontrib><creatorcontrib>Fathman, C G</creatorcontrib><title>Local delivery of interleukin 4 by retrovirus-transduced T lymphocytes ameliorates experimental autoimmune encephalomyelitis</title><title>The Journal of experimental medicine</title><addtitle>J Exp Med</addtitle><description>Experimental autoimmune encephalomyelitis (EAE) is an inflammatory autoimmune disease of the central nervous system which serves as a model for the human disease multiple sclerosis. We demonstrate here that encephalitogenic T cells, transduced with a retroviral gene, construct to express interleukin 4, and can delay the onset and reduce the severity of EAE when adoptively transferred to myelin basic protein-immunized mice. Thus, T lymphocytes transduced with retroviral vectors can deliver "regulatory cytokines" in a site-specific manner and may represent a viable therapeutic strategy for the treatment of autoimmune disease.</description><subject>Animals</subject><subject>Brief Definitive Report</subject><subject>Encephalomyelitis, Autoimmune, Experimental - therapy</subject><subject>Genetic Therapy</subject><subject>Genetic Vectors</subject><subject>Immunization, Passive</subject><subject>Immunotherapy</subject><subject>Interleukin-10 - biosynthesis</subject><subject>Interleukin-4 - administration & dosage</subject><subject>Interleukin-4 - biosynthesis</subject><subject>Mice</subject><subject>Myelin Basic Protein - immunology</subject><subject>Receptors, Antigen, T-Cell - metabolism</subject><subject>Retroviridae - genetics</subject><subject>T-Lymphocytes</subject><subject>Transduction, Genetic</subject><issn>0022-1007</issn><issn>1540-9538</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1r3DAQhkVpSLdJr70VdOrN7ows29KlUEL6AQu5JGehlWe7Sm3Lleylhv74askS2lNPI5hHD-_wMvYWoURQ8sMjDSWqutQltogv2AZrCYWuK_WSbQCEKBCgfcVep_QIgFLWzSW71FijBrVhv7fB2Z531PsjxZWHPffjTLGn5YcfueS7lUeaYzj6uKRijnZM3eKo4_e8X4fpENw6U-J2yIYQ7elNvyaKfqBxzma7zMEPwzISp9HRdLB9GNYMzz5ds4u97RO9Oc8r9vD59v7ma7G9-_Lt5tO2cBKbuVDUaZCVdEIhqY4qoZxVnYNWYSM6C6gaBATSta2g1SjUTguh64Y6ECCqK_bxyTstu4E6l5NF25sph7RxNcF68-9m9AfzPRyNQN0I3WTB-7Mghp8LpdkMPjnqeztSWJJpldayqdr_gthAnVPLDJZPoIshpUj75zQI5lSsycWaXKzR5lRs_vDu7xue8XOT1R-W66K8</recordid><startdate>19970505</startdate><enddate>19970505</enddate><creator>Shaw, M K</creator><creator>Lorens, J B</creator><creator>Dhawan, A</creator><creator>DalCanto, R</creator><creator>Tse, H Y</creator><creator>Tran, A B</creator><creator>Bonpane, C</creator><creator>Eswaran, S L</creator><creator>Brocke, S</creator><creator>Sarvetnick, N</creator><creator>Steinman, L</creator><creator>Nolan, G P</creator><creator>Fathman, C G</creator><general>The Rockefeller University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7T5</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19970505</creationdate><title>Local delivery of interleukin 4 by retrovirus-transduced T lymphocytes ameliorates experimental autoimmune encephalomyelitis</title><author>Shaw, M K ; 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| subjects | Animals Brief Definitive Report Encephalomyelitis, Autoimmune, Experimental - therapy Genetic Therapy Genetic Vectors Immunization, Passive Immunotherapy Interleukin-10 - biosynthesis Interleukin-4 - administration & dosage Interleukin-4 - biosynthesis Mice Myelin Basic Protein - immunology Receptors, Antigen, T-Cell - metabolism Retroviridae - genetics T-Lymphocytes Transduction, Genetic |
| title | Local delivery of interleukin 4 by retrovirus-transduced T lymphocytes ameliorates experimental autoimmune encephalomyelitis |
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