Social Contextual Factors Associated with Entry into Opiate Agonist Treatment Among Injection Drug Users

We tested hypotheses that social living arrangement and drug use in one's network are independently associated with entry into opiate agonist treatment modalities. Injection drug users (IDUs) attending the Baltimore Needle Exchange Program who received a referral for drug abuse treatment were s...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:The American journal of drug and alcohol abuse 2005-01, Vol.31 (4), p.555-570
Hauptverfasser: Lloyd, Jacqueline J., Ricketts, Erin P., Strathdee, Steffanie A., Cornelius, Llewellyn J., Bishai, David, Huettner, Steven, Havens, Jennifer R., Latkin, Carl
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 570
container_issue 4
container_start_page 555
container_title The American journal of drug and alcohol abuse
container_volume 31
creator Lloyd, Jacqueline J.
Ricketts, Erin P.
Strathdee, Steffanie A.
Cornelius, Llewellyn J.
Bishai, David
Huettner, Steven
Havens, Jennifer R.
Latkin, Carl
description We tested hypotheses that social living arrangement and drug use in one's network are independently associated with entry into opiate agonist treatment modalities. Injection drug users (IDUs) attending the Baltimore Needle Exchange Program who received a referral for drug abuse treatment were studied. Baseline interviews, HIV testing, and the Addiction Severity Index (ASI) were administered. Agency records were used to confirm entry into a treatment program offering opiate agonist maintenance therapy within 30 days of the baseline interview. Logistic regression was used to identify predictors of treatment entry. To date, of 245 IDUs, 39% entered such a program. Multivariate logistic regression models controlling for age and intervention status revealed that compared to individuals who lived alone, in a controlled, or nonstable environment (e.g., streets, abandoned house, transitional housing program, or boarding house), individuals who lived with a sexual partner were 3 times more likely to enter treatment (adjusted Odds Ratio [aOR] = 3.04; p = 0.013) and those who lived with family or friends were almost 3 times more likely to enter treatment (aOR = 2.72; p = 0.016). In the bivariate analyses, a marginal association was observed between being responsible for children or others and entry into treatment (p = 0.066); however, this association was not significant in the multivariate model. Findings from this study suggest that supportive living environments may facilitate entry into treatment and may be helpful in devising appropriate and targeted interventions to encourage drug treatment entry.
doi_str_mv 10.1081/ADA-200068114
format Article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2196226</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>935938421</sourcerecordid><originalsourceid>FETCH-LOGICAL-c632t-4e49604613dafb3bb763e315ddce2b60e3e6e091a2217e9381b1b35f3895d0eb3</originalsourceid><addsrcrecordid>eNqFks1v1DAQxS0EokvhyBVZSHAL-CMf9gUp2rZQqVIPtGfLSSa7XiX2Yjst-9_jaJcuRaCebHl-7_nNaBB6S8knSgT9XJ_VGSOElILS_BlaUCKrTApJn6MFIbLImJTkBL0KYZMoKqr8JTqhJWck5_kCrb-71ugBL52N8DNO6Xqh2-h8wHUIcy1Ch-9NXONzG_0OGxsdvt7O77heOWtCxDcedBzBRlyPzq7wpd1AG42z-MxPK3wbwIfX6EWvhwBvDucpur04v1l-y66uv14u66usTZlilkMuS5KXlHe6b3jTVCUHTouua4E1JQEOJRBJNWO0AskFbWjDi54LWXQEGn6Kvux9t1MzQlKl1HpQW29G7XfKaaMeV6xZq5W7U4zKkrEyGXw8GHj3Y4IQ1WhCC8OgLbgpqBRNSMnpk2AhpSyEYE-DFaPJdP76_V_gxk3epnHN6XjOSsETlO2h1rsQPPQPvVGi5pVQaSXUw0ok_t2fAznShx1IwIcDoEOrh95r25pw5CrGRVWRxIk9Z2zv_KjvnR86FfVucP63iP8vQ_VIugY9xHWrPRw7_LfyF0wp4v4</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>219342683</pqid></control><display><type>article</type><title>Social Contextual Factors Associated with Entry into Opiate Agonist Treatment Among Injection Drug Users</title><source>Applied Social Sciences Index &amp; Abstracts (ASSIA)</source><source>Taylor &amp; Francis</source><source>MEDLINE</source><source>Taylor &amp; Francis Medical Library - CRKN</source><source>Sociological Abstracts</source><creator>Lloyd, Jacqueline J. ; Ricketts, Erin P. ; Strathdee, Steffanie A. ; Cornelius, Llewellyn J. ; Bishai, David ; Huettner, Steven ; Havens, Jennifer R. ; Latkin, Carl</creator><creatorcontrib>Lloyd, Jacqueline J. ; Ricketts, Erin P. ; Strathdee, Steffanie A. ; Cornelius, Llewellyn J. ; Bishai, David ; Huettner, Steven ; Havens, Jennifer R. ; Latkin, Carl</creatorcontrib><description>We tested hypotheses that social living arrangement and drug use in one's network are independently associated with entry into opiate agonist treatment modalities. Injection drug users (IDUs) attending the Baltimore Needle Exchange Program who received a referral for drug abuse treatment were studied. Baseline interviews, HIV testing, and the Addiction Severity Index (ASI) were administered. Agency records were used to confirm entry into a treatment program offering opiate agonist maintenance therapy within 30 days of the baseline interview. Logistic regression was used to identify predictors of treatment entry. To date, of 245 IDUs, 39% entered such a program. Multivariate logistic regression models controlling for age and intervention status revealed that compared to individuals who lived alone, in a controlled, or nonstable environment (e.g., streets, abandoned house, transitional housing program, or boarding house), individuals who lived with a sexual partner were 3 times more likely to enter treatment (adjusted Odds Ratio [aOR] = 3.04; p = 0.013) and those who lived with family or friends were almost 3 times more likely to enter treatment (aOR = 2.72; p = 0.016). In the bivariate analyses, a marginal association was observed between being responsible for children or others and entry into treatment (p = 0.066); however, this association was not significant in the multivariate model. Findings from this study suggest that supportive living environments may facilitate entry into treatment and may be helpful in devising appropriate and targeted interventions to encourage drug treatment entry.</description><identifier>ISSN: 0095-2990</identifier><identifier>EISSN: 1097-9891</identifier><identifier>DOI: 10.1081/ADA-200068114</identifier><identifier>PMID: 16320434</identifier><identifier>CODEN: AJDABD</identifier><language>eng</language><publisher>Colchester: Informa UK Ltd</publisher><subject>Addictive behaviors ; Adult ; Adult and adolescent clinical studies ; Biological and medical sciences ; Drug abuse ; Drug addiction ; Drug Injection ; Female ; Fundamental and applied biological sciences. Psychology ; HIV Infections - epidemiology ; Humans ; injection drug users ; Intervention ; living arrangement ; Male ; Medical sciences ; Methadone - therapeutic use ; Narcotics ; Narcotics - therapeutic use ; Needle Exchange Programs ; Opiates ; Prospective Studies ; Psychoanalysis ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Severity of Illness Index ; Social Environment ; Social factors ; Social network ; Social Networks ; Social Support ; Sociodemographic Characteristics ; Substance abuse treatment ; Substance Abuse, Intravenous - diagnosis ; Substance Abuse, Intravenous - epidemiology ; Substance Abuse, Intravenous - rehabilitation ; Toxicology ; Treatment ; Treatment Programs</subject><ispartof>The American journal of drug and alcohol abuse, 2005-01, Vol.31 (4), p.555-570</ispartof><rights>2005 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 2005</rights><rights>2005 INIST-CNRS</rights><rights>Copyright Marcel Dekker, Inc. Nov 2005</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c632t-4e49604613dafb3bb763e315ddce2b60e3e6e091a2217e9381b1b35f3895d0eb3</citedby><cites>FETCH-LOGICAL-c632t-4e49604613dafb3bb763e315ddce2b60e3e6e091a2217e9381b1b35f3895d0eb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1081/ADA-200068114$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1081/ADA-200068114$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,30976,30977,33751,33752,59620,59726,60409,60515,61194,61229,61375,61410</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=17238770$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16320434$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lloyd, Jacqueline J.</creatorcontrib><creatorcontrib>Ricketts, Erin P.</creatorcontrib><creatorcontrib>Strathdee, Steffanie A.</creatorcontrib><creatorcontrib>Cornelius, Llewellyn J.</creatorcontrib><creatorcontrib>Bishai, David</creatorcontrib><creatorcontrib>Huettner, Steven</creatorcontrib><creatorcontrib>Havens, Jennifer R.</creatorcontrib><creatorcontrib>Latkin, Carl</creatorcontrib><title>Social Contextual Factors Associated with Entry into Opiate Agonist Treatment Among Injection Drug Users</title><title>The American journal of drug and alcohol abuse</title><addtitle>Am J Drug Alcohol Abuse</addtitle><description>We tested hypotheses that social living arrangement and drug use in one's network are independently associated with entry into opiate agonist treatment modalities. Injection drug users (IDUs) attending the Baltimore Needle Exchange Program who received a referral for drug abuse treatment were studied. Baseline interviews, HIV testing, and the Addiction Severity Index (ASI) were administered. Agency records were used to confirm entry into a treatment program offering opiate agonist maintenance therapy within 30 days of the baseline interview. Logistic regression was used to identify predictors of treatment entry. To date, of 245 IDUs, 39% entered such a program. Multivariate logistic regression models controlling for age and intervention status revealed that compared to individuals who lived alone, in a controlled, or nonstable environment (e.g., streets, abandoned house, transitional housing program, or boarding house), individuals who lived with a sexual partner were 3 times more likely to enter treatment (adjusted Odds Ratio [aOR] = 3.04; p = 0.013) and those who lived with family or friends were almost 3 times more likely to enter treatment (aOR = 2.72; p = 0.016). In the bivariate analyses, a marginal association was observed between being responsible for children or others and entry into treatment (p = 0.066); however, this association was not significant in the multivariate model. Findings from this study suggest that supportive living environments may facilitate entry into treatment and may be helpful in devising appropriate and targeted interventions to encourage drug treatment entry.</description><subject>Addictive behaviors</subject><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Biological and medical sciences</subject><subject>Drug abuse</subject><subject>Drug addiction</subject><subject>Drug Injection</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>HIV Infections - epidemiology</subject><subject>Humans</subject><subject>injection drug users</subject><subject>Intervention</subject><subject>living arrangement</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Methadone - therapeutic use</subject><subject>Narcotics</subject><subject>Narcotics - therapeutic use</subject><subject>Needle Exchange Programs</subject><subject>Opiates</subject><subject>Prospective Studies</subject><subject>Psychoanalysis</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Severity of Illness Index</subject><subject>Social Environment</subject><subject>Social factors</subject><subject>Social network</subject><subject>Social Networks</subject><subject>Social Support</subject><subject>Sociodemographic Characteristics</subject><subject>Substance abuse treatment</subject><subject>Substance Abuse, Intravenous - diagnosis</subject><subject>Substance Abuse, Intravenous - epidemiology</subject><subject>Substance Abuse, Intravenous - rehabilitation</subject><subject>Toxicology</subject><subject>Treatment</subject><subject>Treatment Programs</subject><issn>0095-2990</issn><issn>1097-9891</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>7QJ</sourceid><sourceid>BHHNA</sourceid><recordid>eNqFks1v1DAQxS0EokvhyBVZSHAL-CMf9gUp2rZQqVIPtGfLSSa7XiX2Yjst-9_jaJcuRaCebHl-7_nNaBB6S8knSgT9XJ_VGSOElILS_BlaUCKrTApJn6MFIbLImJTkBL0KYZMoKqr8JTqhJWck5_kCrb-71ugBL52N8DNO6Xqh2-h8wHUIcy1Ch-9NXONzG_0OGxsdvt7O77heOWtCxDcedBzBRlyPzq7wpd1AG42z-MxPK3wbwIfX6EWvhwBvDucpur04v1l-y66uv14u66usTZlilkMuS5KXlHe6b3jTVCUHTouua4E1JQEOJRBJNWO0AskFbWjDi54LWXQEGn6Kvux9t1MzQlKl1HpQW29G7XfKaaMeV6xZq5W7U4zKkrEyGXw8GHj3Y4IQ1WhCC8OgLbgpqBRNSMnpk2AhpSyEYE-DFaPJdP76_V_gxk3epnHN6XjOSsETlO2h1rsQPPQPvVGi5pVQaSXUw0ok_t2fAznShx1IwIcDoEOrh95r25pw5CrGRVWRxIk9Z2zv_KjvnR86FfVucP63iP8vQ_VIugY9xHWrPRw7_LfyF0wp4v4</recordid><startdate>20050101</startdate><enddate>20050101</enddate><creator>Lloyd, Jacqueline J.</creator><creator>Ricketts, Erin P.</creator><creator>Strathdee, Steffanie A.</creator><creator>Cornelius, Llewellyn J.</creator><creator>Bishai, David</creator><creator>Huettner, Steven</creator><creator>Havens, Jennifer R.</creator><creator>Latkin, Carl</creator><general>Informa UK Ltd</general><general>Taylor &amp; Francis</general><general>Taylor &amp; Francis Ltd</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QJ</scope><scope>7U3</scope><scope>BHHNA</scope><scope>K7.</scope><scope>K9.</scope><scope>7U4</scope><scope>DWI</scope><scope>WZK</scope><scope>5PM</scope></search><sort><creationdate>20050101</creationdate><title>Social Contextual Factors Associated with Entry into Opiate Agonist Treatment Among Injection Drug Users</title><author>Lloyd, Jacqueline J. ; Ricketts, Erin P. ; Strathdee, Steffanie A. ; Cornelius, Llewellyn J. ; Bishai, David ; Huettner, Steven ; Havens, Jennifer R. ; Latkin, Carl</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c632t-4e49604613dafb3bb763e315ddce2b60e3e6e091a2217e9381b1b35f3895d0eb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Addictive behaviors</topic><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Biological and medical sciences</topic><topic>Drug abuse</topic><topic>Drug addiction</topic><topic>Drug Injection</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>HIV Infections - epidemiology</topic><topic>Humans</topic><topic>injection drug users</topic><topic>Intervention</topic><topic>living arrangement</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Methadone - therapeutic use</topic><topic>Narcotics</topic><topic>Narcotics - therapeutic use</topic><topic>Needle Exchange Programs</topic><topic>Opiates</topic><topic>Prospective Studies</topic><topic>Psychoanalysis</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Severity of Illness Index</topic><topic>Social Environment</topic><topic>Social factors</topic><topic>Social network</topic><topic>Social Networks</topic><topic>Social Support</topic><topic>Sociodemographic Characteristics</topic><topic>Substance abuse treatment</topic><topic>Substance Abuse, Intravenous - diagnosis</topic><topic>Substance Abuse, Intravenous - epidemiology</topic><topic>Substance Abuse, Intravenous - rehabilitation</topic><topic>Toxicology</topic><topic>Treatment</topic><topic>Treatment Programs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lloyd, Jacqueline J.</creatorcontrib><creatorcontrib>Ricketts, Erin P.</creatorcontrib><creatorcontrib>Strathdee, Steffanie A.</creatorcontrib><creatorcontrib>Cornelius, Llewellyn J.</creatorcontrib><creatorcontrib>Bishai, David</creatorcontrib><creatorcontrib>Huettner, Steven</creatorcontrib><creatorcontrib>Havens, Jennifer R.</creatorcontrib><creatorcontrib>Latkin, Carl</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Applied Social Sciences Index &amp; Abstracts (ASSIA)</collection><collection>Social Services Abstracts</collection><collection>Sociological Abstracts</collection><collection>ProQuest Criminal Justice (Alumni)</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Sociological Abstracts (pre-2017)</collection><collection>Sociological Abstracts</collection><collection>Sociological Abstracts (Ovid)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The American journal of drug and alcohol abuse</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lloyd, Jacqueline J.</au><au>Ricketts, Erin P.</au><au>Strathdee, Steffanie A.</au><au>Cornelius, Llewellyn J.</au><au>Bishai, David</au><au>Huettner, Steven</au><au>Havens, Jennifer R.</au><au>Latkin, Carl</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Social Contextual Factors Associated with Entry into Opiate Agonist Treatment Among Injection Drug Users</atitle><jtitle>The American journal of drug and alcohol abuse</jtitle><addtitle>Am J Drug Alcohol Abuse</addtitle><date>2005-01-01</date><risdate>2005</risdate><volume>31</volume><issue>4</issue><spage>555</spage><epage>570</epage><pages>555-570</pages><issn>0095-2990</issn><eissn>1097-9891</eissn><coden>AJDABD</coden><abstract>We tested hypotheses that social living arrangement and drug use in one's network are independently associated with entry into opiate agonist treatment modalities. Injection drug users (IDUs) attending the Baltimore Needle Exchange Program who received a referral for drug abuse treatment were studied. Baseline interviews, HIV testing, and the Addiction Severity Index (ASI) were administered. Agency records were used to confirm entry into a treatment program offering opiate agonist maintenance therapy within 30 days of the baseline interview. Logistic regression was used to identify predictors of treatment entry. To date, of 245 IDUs, 39% entered such a program. Multivariate logistic regression models controlling for age and intervention status revealed that compared to individuals who lived alone, in a controlled, or nonstable environment (e.g., streets, abandoned house, transitional housing program, or boarding house), individuals who lived with a sexual partner were 3 times more likely to enter treatment (adjusted Odds Ratio [aOR] = 3.04; p = 0.013) and those who lived with family or friends were almost 3 times more likely to enter treatment (aOR = 2.72; p = 0.016). In the bivariate analyses, a marginal association was observed between being responsible for children or others and entry into treatment (p = 0.066); however, this association was not significant in the multivariate model. Findings from this study suggest that supportive living environments may facilitate entry into treatment and may be helpful in devising appropriate and targeted interventions to encourage drug treatment entry.</abstract><cop>Colchester</cop><pub>Informa UK Ltd</pub><pmid>16320434</pmid><doi>10.1081/ADA-200068114</doi><tpages>16</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0095-2990
ispartof The American journal of drug and alcohol abuse, 2005-01, Vol.31 (4), p.555-570
issn 0095-2990
1097-9891
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2196226
source Applied Social Sciences Index & Abstracts (ASSIA); Taylor & Francis; MEDLINE; Taylor & Francis Medical Library - CRKN; Sociological Abstracts
subjects Addictive behaviors
Adult
Adult and adolescent clinical studies
Biological and medical sciences
Drug abuse
Drug addiction
Drug Injection
Female
Fundamental and applied biological sciences. Psychology
HIV Infections - epidemiology
Humans
injection drug users
Intervention
living arrangement
Male
Medical sciences
Methadone - therapeutic use
Narcotics
Narcotics - therapeutic use
Needle Exchange Programs
Opiates
Prospective Studies
Psychoanalysis
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Severity of Illness Index
Social Environment
Social factors
Social network
Social Networks
Social Support
Sociodemographic Characteristics
Substance abuse treatment
Substance Abuse, Intravenous - diagnosis
Substance Abuse, Intravenous - epidemiology
Substance Abuse, Intravenous - rehabilitation
Toxicology
Treatment
Treatment Programs
title Social Contextual Factors Associated with Entry into Opiate Agonist Treatment Among Injection Drug Users
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-05T15%3A22%3A39IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Social%20Contextual%20Factors%20Associated%20with%20Entry%20into%20Opiate%20Agonist%20Treatment%20Among%20Injection%20Drug%20Users&rft.jtitle=The%20American%20journal%20of%20drug%20and%20alcohol%20abuse&rft.au=Lloyd,%20Jacqueline%20J.&rft.date=2005-01-01&rft.volume=31&rft.issue=4&rft.spage=555&rft.epage=570&rft.pages=555-570&rft.issn=0095-2990&rft.eissn=1097-9891&rft.coden=AJDABD&rft_id=info:doi/10.1081/ADA-200068114&rft_dat=%3Cproquest_pubme%3E935938421%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=219342683&rft_id=info:pmid/16320434&rfr_iscdi=true