Cross-presentation of disialoganglioside GD3 to natural killer T cells

GD3, a ganglioside expressed on human melanoma, can be recognized by the humoral immune system. In this paper, we demonstrate that immunizing mice with the human melanoma cell line SK-MEL-28 (GD3+ GM2- CD1-) or with syngeneic APCs loaded with GD3 can induce a GD3-reactive natural killer T (NKT) cell...

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Veröffentlicht in:	The Journal of experimental medicine 2003-07, Vol.198 (1), p.173-181
Hauptverfasser:	Wu, Dianna Y, Segal, Neil H, Sidobre, Stephane, Kronenberg, Mitchell, Chapman, Paul B
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Antigen Presentation Antigen-Presenting Cells - physiology Antigens, CD1 - physiology Antigens, CD1d Cytokines - biosynthesis Female Galactosylceramides - pharmacology Gangliosides - immunology Humans Immunization Killer Cells, Natural - immunology Mice Mice, Inbred C57BL Molecular Sequence Data
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