The relative importance of T cell subsets in immunity and immunopathology of airborne Mycobacterium tuberculosis infection in mice

Wild-type (WT) and targeted-mutant mice incapable of making alphabeta T cells, gammadelta T cells, class I major histocompatibility complex (MHC), class II MHC, interferon (IFN)-gamma, or inducible nitric oxide synthase (NOS2), were infected with Mycobacterium tuberculosis (Mtb) by aerosol, and moni...

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Veröffentlicht in:	The Journal of experimental medicine 2001-02, Vol.193 (3), p.271-280
Hauptverfasser:	Mogues, T, Goodrich, M E, Ryan, L, LaCourse, R, North, R J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals beta 2-Microglobulin - genetics beta 2-Microglobulin - immunology CD4 antigen CD4-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - immunology Disease Models, Animal g-Interferon H-2 Antigens - genetics H-2 Antigens - immunology Interferon-gamma - genetics Interferon-gamma - immunology Lung - immunology Lung - pathology Mice Mice, Inbred C57BL Mice, Knockout Mycobacterium tuberculosis Mycobacterium tuberculosis - growth & development Mycobacterium tuberculosis - immunology Nitric Oxide Synthase - genetics Nitric Oxide Synthase - immunology Nitric Oxide Synthase Type II Original Receptors, Antigen, T-Cell, alpha-beta - genetics Receptors, Antigen, T-Cell, alpha-beta - immunology Receptors, Antigen, T-Cell, gamma-delta - genetics Receptors, Antigen, T-Cell, gamma-delta - immunology RNA, Messenger - biosynthesis Tuberculosis - immunology Tuberculosis - microbiology Tuberculosis - pathology
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