Caspase-11 mediates oligodendrocyte cell death and pathogenesis of autoimmune-mediated demyelination
Multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE), are inflammatory diseases of the central nervous system (CNS) characterized by localized areas of demyelination. The mechanisms underlying oligodendrocyte (OLG) injury in MS and EAE remain unknown. Here we...
Gespeichert in:
| Veröffentlicht in: | The Journal of experimental medicine 2001-01, Vol.193 (1), p.111-122 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 122 |
|---|---|
| container_issue | 1 |
| container_start_page | 111 |
| container_title | The Journal of experimental medicine |
| container_volume | 193 |
| creator | Hisahara, S Yuan, J Momoi, T Okano, H Miura, M |
| description | Multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE), are inflammatory diseases of the central nervous system (CNS) characterized by localized areas of demyelination. The mechanisms underlying oligodendrocyte (OLG) injury in MS and EAE remain unknown. Here we show that caspase-11 plays crucial roles in OLG death and pathogenesis in EAE. Caspase-11 and activated caspase-3 were both expressed in OLGs in spinal cord EAE lesions. OLGs from caspase-11-deficient mice were highly resistant to the cell death induced by cytotoxic cytokines. EAE susceptibility and cytokine concentrations in the CNS were significantly reduced in caspase-11-deficient mice. Our findings suggest that OLG death is mediated by a pathway that involves caspases-11 and -3 and leads to the demyelination observed in EAE. |
| doi_str_mv | 10.1084/jem.193.1.111 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2195881</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>70568224</sourcerecordid><originalsourceid>FETCH-LOGICAL-c480t-fff112760226d06e76b777a3e91eda827f0f831cde4f96882b34651e1bda5cc3</originalsourceid><addsrcrecordid>eNqFkU1LAzEQhoMoWqtHr7Inb1sz2d0kexGk-AWCF-8h3UzalN2kbnaF_ntTWvw4eZrAPLy8k4eQK6AzoLK8XWM3g7qYwQwAjsgEqpLmdVXIYzKhlLEcKBVn5DzGNaVQlhU_JWcJLbhk1YSYuY4bHTEHyDo0Tg8Ys9C6ZTDoTR-a7YBZg22bGdTDKtPeZJv0CEv0GF1ibabHIbiuGz3mhwiT6G6LrfN6cMFfkBOr24iXhzkl748P7_Pn_PXt6WV-_5o3paRDbq0FYIKn1txQjoIvhBC6wBrQaMmEpVYW0Bgsbc2lZIui5BUgLIyumqaYkrt97GZcpCIN-qHXrdr0rtP9VgXt1N-Ndyu1DJ-KQV1JCSng5hDQh48R46A6F3fHa49hjErQKv0aK_8FQUgGnNEE5nuw6UOMPdrvNkDVzp9K_lTyp0DtpEzJ9e8TfuiDsOILILKZNg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>17821620</pqid></control><display><type>article</type><title>Caspase-11 mediates oligodendrocyte cell death and pathogenesis of autoimmune-mediated demyelination</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Hisahara, S ; Yuan, J ; Momoi, T ; Okano, H ; Miura, M</creator><creatorcontrib>Hisahara, S ; Yuan, J ; Momoi, T ; Okano, H ; Miura, M</creatorcontrib><description>Multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE), are inflammatory diseases of the central nervous system (CNS) characterized by localized areas of demyelination. The mechanisms underlying oligodendrocyte (OLG) injury in MS and EAE remain unknown. Here we show that caspase-11 plays crucial roles in OLG death and pathogenesis in EAE. Caspase-11 and activated caspase-3 were both expressed in OLGs in spinal cord EAE lesions. OLGs from caspase-11-deficient mice were highly resistant to the cell death induced by cytotoxic cytokines. EAE susceptibility and cytokine concentrations in the CNS were significantly reduced in caspase-11-deficient mice. Our findings suggest that OLG death is mediated by a pathway that involves caspases-11 and -3 and leads to the demyelination observed in EAE.</description><identifier>ISSN: 0022-1007</identifier><identifier>EISSN: 1540-9538</identifier><identifier>EISSN: 1892-1007</identifier><identifier>DOI: 10.1084/jem.193.1.111</identifier><identifier>PMID: 11136825</identifier><language>eng</language><publisher>United States: The Rockefeller University Press</publisher><subject>Animals ; Apoptosis ; Base Sequence ; Caspase 3 ; Caspases - deficiency ; Caspases - genetics ; Caspases - metabolism ; Caspases - physiology ; Demyelinating Diseases - etiology ; DNA Primers - genetics ; Encephalomyelitis, Autoimmune, Experimental - enzymology ; Encephalomyelitis, Autoimmune, Experimental - etiology ; Encephalomyelitis, Autoimmune, Experimental - immunology ; Enzyme Activation ; Female ; Humans ; Male ; Mice ; Mice, Inbred C3H ; Mice, Inbred C57BL ; Mice, Knockout ; Multiple Sclerosis - etiology ; Oligodendroglia - cytology ; Oligodendroglia - enzymology ; Oligodendroglia - immunology ; Original ; Pregnancy ; Spinal Cord - enzymology</subject><ispartof>The Journal of experimental medicine, 2001-01, Vol.193 (1), p.111-122</ispartof><rights>2001 The Rockefeller University Press 2001 The Rockefeller University Press</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c480t-fff112760226d06e76b777a3e91eda827f0f831cde4f96882b34651e1bda5cc3</citedby><cites>FETCH-LOGICAL-c480t-fff112760226d06e76b777a3e91eda827f0f831cde4f96882b34651e1bda5cc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11136825$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hisahara, S</creatorcontrib><creatorcontrib>Yuan, J</creatorcontrib><creatorcontrib>Momoi, T</creatorcontrib><creatorcontrib>Okano, H</creatorcontrib><creatorcontrib>Miura, M</creatorcontrib><title>Caspase-11 mediates oligodendrocyte cell death and pathogenesis of autoimmune-mediated demyelination</title><title>The Journal of experimental medicine</title><addtitle>J Exp Med</addtitle><description>Multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE), are inflammatory diseases of the central nervous system (CNS) characterized by localized areas of demyelination. The mechanisms underlying oligodendrocyte (OLG) injury in MS and EAE remain unknown. Here we show that caspase-11 plays crucial roles in OLG death and pathogenesis in EAE. Caspase-11 and activated caspase-3 were both expressed in OLGs in spinal cord EAE lesions. OLGs from caspase-11-deficient mice were highly resistant to the cell death induced by cytotoxic cytokines. EAE susceptibility and cytokine concentrations in the CNS were significantly reduced in caspase-11-deficient mice. Our findings suggest that OLG death is mediated by a pathway that involves caspases-11 and -3 and leads to the demyelination observed in EAE.</description><subject>Animals</subject><subject>Apoptosis</subject><subject>Base Sequence</subject><subject>Caspase 3</subject><subject>Caspases - deficiency</subject><subject>Caspases - genetics</subject><subject>Caspases - metabolism</subject><subject>Caspases - physiology</subject><subject>Demyelinating Diseases - etiology</subject><subject>DNA Primers - genetics</subject><subject>Encephalomyelitis, Autoimmune, Experimental - enzymology</subject><subject>Encephalomyelitis, Autoimmune, Experimental - etiology</subject><subject>Encephalomyelitis, Autoimmune, Experimental - immunology</subject><subject>Enzyme Activation</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred C3H</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Knockout</subject><subject>Multiple Sclerosis - etiology</subject><subject>Oligodendroglia - cytology</subject><subject>Oligodendroglia - enzymology</subject><subject>Oligodendroglia - immunology</subject><subject>Original</subject><subject>Pregnancy</subject><subject>Spinal Cord - enzymology</subject><issn>0022-1007</issn><issn>1540-9538</issn><issn>1892-1007</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1LAzEQhoMoWqtHr7Inb1sz2d0kexGk-AWCF-8h3UzalN2kbnaF_ntTWvw4eZrAPLy8k4eQK6AzoLK8XWM3g7qYwQwAjsgEqpLmdVXIYzKhlLEcKBVn5DzGNaVQlhU_JWcJLbhk1YSYuY4bHTEHyDo0Tg8Ys9C6ZTDoTR-a7YBZg22bGdTDKtPeZJv0CEv0GF1ibabHIbiuGz3mhwiT6G6LrfN6cMFfkBOr24iXhzkl748P7_Pn_PXt6WV-_5o3paRDbq0FYIKn1txQjoIvhBC6wBrQaMmEpVYW0Bgsbc2lZIui5BUgLIyumqaYkrt97GZcpCIN-qHXrdr0rtP9VgXt1N-Ndyu1DJ-KQV1JCSng5hDQh48R46A6F3fHa49hjErQKv0aK_8FQUgGnNEE5nuw6UOMPdrvNkDVzp9K_lTyp0DtpEzJ9e8TfuiDsOILILKZNg</recordid><startdate>20010101</startdate><enddate>20010101</enddate><creator>Hisahara, S</creator><creator>Yuan, J</creator><creator>Momoi, T</creator><creator>Okano, H</creator><creator>Miura, M</creator><general>The Rockefeller University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20010101</creationdate><title>Caspase-11 mediates oligodendrocyte cell death and pathogenesis of autoimmune-mediated demyelination</title><author>Hisahara, S ; Yuan, J ; Momoi, T ; Okano, H ; Miura, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c480t-fff112760226d06e76b777a3e91eda827f0f831cde4f96882b34651e1bda5cc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Animals</topic><topic>Apoptosis</topic><topic>Base Sequence</topic><topic>Caspase 3</topic><topic>Caspases - deficiency</topic><topic>Caspases - genetics</topic><topic>Caspases - metabolism</topic><topic>Caspases - physiology</topic><topic>Demyelinating Diseases - etiology</topic><topic>DNA Primers - genetics</topic><topic>Encephalomyelitis, Autoimmune, Experimental - enzymology</topic><topic>Encephalomyelitis, Autoimmune, Experimental - etiology</topic><topic>Encephalomyelitis, Autoimmune, Experimental - immunology</topic><topic>Enzyme Activation</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred C3H</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Knockout</topic><topic>Multiple Sclerosis - etiology</topic><topic>Oligodendroglia - cytology</topic><topic>Oligodendroglia - enzymology</topic><topic>Oligodendroglia - immunology</topic><topic>Original</topic><topic>Pregnancy</topic><topic>Spinal Cord - enzymology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hisahara, S</creatorcontrib><creatorcontrib>Yuan, J</creatorcontrib><creatorcontrib>Momoi, T</creatorcontrib><creatorcontrib>Okano, H</creatorcontrib><creatorcontrib>Miura, M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of experimental medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hisahara, S</au><au>Yuan, J</au><au>Momoi, T</au><au>Okano, H</au><au>Miura, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Caspase-11 mediates oligodendrocyte cell death and pathogenesis of autoimmune-mediated demyelination</atitle><jtitle>The Journal of experimental medicine</jtitle><addtitle>J Exp Med</addtitle><date>2001-01-01</date><risdate>2001</risdate><volume>193</volume><issue>1</issue><spage>111</spage><epage>122</epage><pages>111-122</pages><issn>0022-1007</issn><eissn>1540-9538</eissn><eissn>1892-1007</eissn><abstract>Multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE), are inflammatory diseases of the central nervous system (CNS) characterized by localized areas of demyelination. The mechanisms underlying oligodendrocyte (OLG) injury in MS and EAE remain unknown. Here we show that caspase-11 plays crucial roles in OLG death and pathogenesis in EAE. Caspase-11 and activated caspase-3 were both expressed in OLGs in spinal cord EAE lesions. OLGs from caspase-11-deficient mice were highly resistant to the cell death induced by cytotoxic cytokines. EAE susceptibility and cytokine concentrations in the CNS were significantly reduced in caspase-11-deficient mice. Our findings suggest that OLG death is mediated by a pathway that involves caspases-11 and -3 and leads to the demyelination observed in EAE.</abstract><cop>United States</cop><pub>The Rockefeller University Press</pub><pmid>11136825</pmid><doi>10.1084/jem.193.1.111</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-1007 |
| ispartof | The Journal of experimental medicine, 2001-01, Vol.193 (1), p.111-122 |
| issn | 0022-1007 1540-9538 1892-1007 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2195881 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animals Apoptosis Base Sequence Caspase 3 Caspases - deficiency Caspases - genetics Caspases - metabolism Caspases - physiology Demyelinating Diseases - etiology DNA Primers - genetics Encephalomyelitis, Autoimmune, Experimental - enzymology Encephalomyelitis, Autoimmune, Experimental - etiology Encephalomyelitis, Autoimmune, Experimental - immunology Enzyme Activation Female Humans Male Mice Mice, Inbred C3H Mice, Inbred C57BL Mice, Knockout Multiple Sclerosis - etiology Oligodendroglia - cytology Oligodendroglia - enzymology Oligodendroglia - immunology Original Pregnancy Spinal Cord - enzymology |
| title | Caspase-11 mediates oligodendrocyte cell death and pathogenesis of autoimmune-mediated demyelination |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-05T14%3A21%3A26IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Caspase-11%20mediates%20oligodendrocyte%20cell%20death%20and%20pathogenesis%20of%20autoimmune-mediated%20demyelination&rft.jtitle=The%20Journal%20of%20experimental%20medicine&rft.au=Hisahara,%20S&rft.date=2001-01-01&rft.volume=193&rft.issue=1&rft.spage=111&rft.epage=122&rft.pages=111-122&rft.issn=0022-1007&rft.eissn=1540-9538&rft_id=info:doi/10.1084/jem.193.1.111&rft_dat=%3Cproquest_pubme%3E70568224%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=17821620&rft_id=info:pmid/11136825&rfr_iscdi=true |