Germinal centers without T cells

Germinal centers are critical for affinity maturation of antibody (Ab) responses. This process allows the production of high-efficiency neutralizing Ab that protects against virus infection and bacterial exotoxins. In germinal centers, responding B cells selectively mutate the genes that encode thei...

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Veröffentlicht in:	The Journal of experimental medicine 2000-02, Vol.191 (3), p.485-494
Hauptverfasser:	de Vinuesa, C G, Cook, M C, Ball, J, Drew, M, Sunners, Y, Cascalho, M, Wabl, M, Klaus, G G, MacLennan, I C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, CD - analysis B-Lymphocytes - physiology B7-1 Antigen - analysis B7-2 Antigen CD40 antigen CD40 Antigens - analysis Ficoll Germinal Center - physiology germinal centers Haptens Membrane Glycoproteins - analysis Mice Mice, Nude Mice, Transgenic Nitrophenols Original Peanut Agglutinin Phenylacetates Signal Transduction Spleen - drug effects T-Lymphocytes - physiology
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