Suppression of T and B lymphocyte activation by a Yersinia pseudotuberculosis virulence factor, yopH

The acquired immune responses are crucial to the survival of Yersinia-infected animals. Mice lacking T cells are sensitive to Yersinia infection, and a humoral response to Yersinia can be protective. Diverse mechanisms for Yersinia to impair and evade the host innate immune defense have been suggest...

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Veröffentlicht in:	The Journal of experimental medicine 1999-11, Vol.190 (9), p.1343-1350
Hauptverfasser:	Yao, T, Mecsas, J, Healy, J I, Falkow, S, Chien, Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, CD - immunology B-Lymphocytes - microbiology B7-2 Antigen Bacterial Outer Membrane Proteins - pharmacology Calcium - metabolism Cell Line Interleukin-2 - immunology Interleukin-2 - metabolism Ionomycin - pharmacology Lymphocyte Activation - immunology Membrane Glycoproteins - immunology Mice Mice, Transgenic Original Phosphorylation Phosphotyrosine - analysis Protein Tyrosine Phosphatases - pharmacology Receptors, Antigen, T-Cell - metabolism Signal Transduction T-Lymphocytes - microbiology Tetradecanoylphorbol Acetate - pharmacology Up-Regulation virulence factors Yersinia pseudotuberculosis Yersinia pseudotuberculosis Infections - immunology YopH protein
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