The catabolism of plasma albumin in the rabbit: its rate and regulation

The catabolism of plasma albumin in the rabbit: its rate and regulation

From I(131)-albumin studies and previously defined mathematical formulations, rates of breakdown were estimated for native plasma albumin in rabbits. These rates of catabolism per unit weight of animal were remarkably constant and were independent of variations in the steady state values of albumin...

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Veröffentlicht in:The Journal of general physiology 1959-11, Vol.43 (2), p.445-453
Hauptverfasser: REEVE, E B, ROBERTS, J E
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Iodine
Iodine Radioisotopes
Old Medline
Rabbits
Serum Albumin - metabolism
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container_title The Journal of general physiology
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creator REEVE, E B
ROBERTS, J E
description From I(131)-albumin studies and previously defined mathematical formulations, rates of breakdown were estimated for native plasma albumin in rabbits. These rates of catabolism per unit weight of animal were remarkably constant and were independent of variations in the steady state values of albumin concentration in the plasma. These results imply that, at least between animals, the breakdown of plasma albumin follows a kinetic process of approximately zero order. It seems plausible that the process operates similarly in individual animals, and hence that albumin is maintained at normal steady state levels in the healthy animal primarily by means of a regulated rate of synthesis.
doi_str_mv 10.1085/jgp.43.2.445
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source MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection
subjects Animals
Iodine
Iodine Radioisotopes
Old Medline
Rabbits
Serum Albumin - metabolism
title The catabolism of plasma albumin in the rabbit: its rate and regulation
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