Intracrine cysteinyl leukotriene receptor-mediated signaling of eosinophil vesicular transport-mediated interleukin-4 secretion

We investigated whether cysteinyl leukotrienes (cysLT) are intracrine signal transducers that regulate human eosinophil degranulation mechanisms. Interleukin (IL)-16, eotaxin, and RANTES stimulate vesicular transport-mediated release of preformed, granule-derived IL-4 and RANTES from eosinophils and...

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Veröffentlicht in:	The Journal of experimental medicine 2002-09, Vol.196 (6), p.841-850
Hauptverfasser:	Bandeira-Melo, Christianne, Woods, Lesley J, Phoofolo, Mojabeng, Weller, Peter F
Format:	Artikel
Sprache:	eng
Schlagworte:	Arachidonate 5-Lipoxygenase - physiology Chemokine CCL5 - metabolism Eosinophils - physiology Humans Interleukin-4 - metabolism Leukotriene C4 - physiology Leukotriene D4 - physiology Membrane Proteins Phosphatidylinositol 3-Kinases - physiology Receptors, CCR3 Receptors, Chemokine - physiology Receptors, Leukotriene - physiology Transport Vesicles - physiology
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