Myeloperoxidase and plasminogen activator inhibitor 1 play a central role in ventricular remodeling after myocardial infarction

Left ventricular (LV) remodeling after myocardial infarction (MI) results in LV dilation, a major cause of congestive heart failure and sudden cardiac death. Ischemic injury and the ensuing inflammatory response participate in LV remodeling, leading to myocardial rupture and LV dilation. Myeloperoxi...

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Veröffentlicht in:	The Journal of experimental medicine 2003-03, Vol.197 (5), p.615-624
Hauptverfasser:	Askari, Arman T, Brennan, Marie-Luise, Zhou, Xiaorong, Drinko, Jeanne, Morehead, Annitta, Thomas, James D, Topol, Eric J, Hazen, Stanley L, Penn, Marc S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Collagen - metabolism Coronary Circulation Enzyme Activation Humans Inflammation Leukocyte Common Antigens - metabolism Leukocytes - metabolism Matrix Metalloproteinase 2 - metabolism Matrix Metalloproteinase 9 - metabolism Mice Mice, Inbred C57BL Mice, Knockout Myocardial Infarction - metabolism Myocardium - cytology Myocardium - metabolism Myocardium - pathology Oxidation-Reduction Peroxidase - genetics Peroxidase - metabolism Plasminogen Activator Inhibitor 1 - metabolism Serine Proteinase Inhibitors - metabolism Survival Rate Time Factors Ventricular Remodeling
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