Secondary heavy chain rearrangement: a mechanism for generating anti-double-stranded DNA B cells

The chronic graft-versus-host (cGVH) reaction results in a syndrome that closely resembles systemic lupus erythematosus (SLE). It is induced in nonautoimmune mice by the transfer of alloreactive T cells. The availability of anti-DNA transgenes allows us to study the genetic origins of autoantibodies...

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Veröffentlicht in:	The Journal of experimental medicine 2003-01, Vol.197 (1), p.27-39
Hauptverfasser:	Sekiguchi, Debora R, Eisenberg, Robert A, Weigert, Martin
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Antibodies, Antinuclear - chemistry Antibodies, Antinuclear - genetics Antibodies, Antinuclear - immunology Antibodies, Monoclonal - immunology Antibody Specificity B-Lymphocytes - immunology Base Sequence DNA - immunology Enzyme-Linked Immunosorbent Assay Gene Rearrangement, B-Lymphocyte - genetics Graft vs Host Disease - immunology Hybridomas - immunology Hybridomas - metabolism Immunoglobulin Allotypes - chemistry Immunoglobulin Allotypes - genetics Immunoglobulin Allotypes - immunology Immunoglobulin G - genetics Immunoglobulin G - immunology Immunoglobulin Heavy Chains - chemistry Immunoglobulin Heavy Chains - genetics Immunoglobulin Heavy Chains - immunology Immunoglobulin Light Chains - chemistry Immunoglobulin Light Chains - genetics Mice Mice, Transgenic Molecular Sequence Data Mutation - genetics Transgenes - genetics
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