The intersectin 2 adaptor links Wiskott Aldrich Syndrome protein (WASp)-mediated actin polymerization to T cell antigen receptor endocytosis

Induction of T cell antigen receptor (TCR) endocytosis has a significant impact on TCR signaling and T cell behavior, but the molecular interactions coordinating internalization of the activated TCR are poorly understood. Previously we have shown that TCR endocytosis is regulated by the Wiskott Aldr...

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Veröffentlicht in:	The Journal of experimental medicine 2001-12, Vol.194 (12), p.1777-1787
Hauptverfasser:	McGavin, M K, Badour, K, Hardy, L A, Kubiseski, T J, Zhang, J, Siminovitch, K A
Format:	Artikel
Sprache:	eng
Schlagworte:	actin Actins - chemistry Actins - immunology Adaptor Proteins, Vesicular Transport Animals Carrier Proteins - immunology COS Cells Dimerization Endocytosis - immunology Humans intersectin 2 Jurkat Cells Lymphocyte Activation Original Proteins - immunology Receptors, Antigen, T-Cell - immunology T-Lymphocytes - immunology WASP protein Wiskott-Aldrich Syndrome Protein
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