Interferon-alpha and interleukin-12 are induced differentially by Toll-like receptor 7 ligands in human blood dendritic cell subsets

Dendritic cells (DCs) play a crucial role in the immune responses against infections by sensing microbial invasion through toll-like receptors (TLRs). In humans, two distinct DC subsets, CD11c(-) plasmacytoid DCs (PDCs) and CD11c(+) myeloid DCs (MDCs), have been identified and can respond to differe...

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Veröffentlicht in:	The Journal of experimental medicine 2002-06, Vol.195 (11), p.1507-1512
Hauptverfasser:	Ito, Tomoki, Amakawa, Ryuichi, Kaisho, Tsuneyasu, Hemmi, Hiroaki, Tajima, Kenichirou, Uehira, Kazutaka, Ozaki, Yoshio, Tomizawa, Hideyuki, Akira, Shizuo, Fukuhara, Shirou
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brief Definitive Report Cell Differentiation Cell Lineage Cell Survival - drug effects Dendritic Cells - cytology Dendritic Cells - drug effects Dendritic Cells - metabolism Drosophila Proteins Humans Interferon-alpha - blood Interferon-alpha - metabolism Interleukin-12 - blood Interleukin-12 - metabolism Ligands Membrane Glycoproteins - agonists Membrane Glycoproteins - genetics Membrane Glycoproteins - metabolism Mice Receptors, Cell Surface - agonists Receptors, Cell Surface - genetics Receptors, Cell Surface - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics RNA, Messenger - metabolism Th1 Cells - cytology Toll-Like Receptor 7 Toll-Like Receptors
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