Telomere shortening accompanies increased cell cycle activity during serial transplantation of hematopoietic stem cells

Reactivation of telomerase and maintenance of telomere length can lead to the prevention of replicative senescence in some human somatic cells grown in vitro. To investigate whether telomere shortening might also play a role in the limitation of hematopoietic stem cell (HSC) division capacity in viv...

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Veröffentlicht in:	The Journal of experimental medicine 2001-04, Vol.193 (8), p.917-924
Hauptverfasser:	Allsopp, R C, Cheshier, S, Weissman, I L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blotting, Southern Bone Marrow Cells - cytology Cell Cycle - physiology Flow Cytometry G2 Phase Hematopoietic Stem Cell Transplantation - methods Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - ultrastructure Humans Mice Mice, Inbred C57BL Mitosis Models, Biological Original S Phase stem cell transplantation Telomere - genetics Telomere - ultrastructure Time Factors Transplantation, Isogeneic - physiology
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