Differential signaling and tumor necrosis factor receptor-associated factor (TRAF) degradation mediated by CD40 and the Epstein-Barr virus oncoprotein latent membrane protein 1 (LMP1)

Latent membrane protein 1 (LMP1) plays a critical role in B cell transformation by Epstein-Barr virus (EBV) and appears to mimic a constitutively active CD40 receptor. Intracellular tumor necrosis factor (TNF) receptor-associated factor (TRAF) adapter proteins, shown to contribute to signaling by bo...

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Veröffentlicht in:	The Journal of experimental medicine 2001-04, Vol.193 (8), p.943-954
Hauptverfasser:	Brown, K D, Hostager, B S, Bishop, G A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals B-Lymphocytes - immunology B-Lymphocytes - virology CD40 antigen CD40 Antigens - genetics CD40 Antigens - physiology Cell Line Cell Membrane - immunology Epstein-Barr virus Herpesvirus 4, Human - physiology Humans latent membrane protein 1 Lymphocyte Activation Mice Original Proteins - metabolism Receptors, Tumor Necrosis Factor - physiology Recombinant Proteins - metabolism Signal Transduction TNF Receptor-Associated Factor 2 TNF Receptor-Associated Factor 3 TRAF2 protein TRAF3 protein Transfection tumor necrosis factor receptors Viral Matrix Proteins - metabolism
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