Candidate microbicides block HIV-1 infection of human immature Langerhans cells within epithelial tissue explants

Initial biologic events that underlie sexual transmission of HIV-1 are poorly understood. To model these events, we exposed human immature Langerhans cells (LCs) within epithelial tissue explants to two primary and two laboratory-adapted HIV-1 isolates. We detected HIV-1(Ba-L) infection in single LC...

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Veröffentlicht in:	The Journal of experimental medicine 2000-11, Vol.192 (10), p.1491-1500
Hauptverfasser:	Kawamura, T, Cohen, S S, Borris, D L, Aquilino, E A, Glushakova, S, Margolis, L B, Orenstein, J M, Offord, R E, Neurath, A R, Blauvelt, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-HIV Agents - pharmacology CD4-Positive T-Lymphocytes - virology Cell Movement Chemokine CCL5 - analogs & derivatives Chemokine CCL5 - pharmacology Coculture Techniques Epithelial Cells - virology HIV Infections - transmission HIV-1 human immunodeficiency virus 1 Humans Langerhans Cells - virology Original
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