The transcription factor interferon regulatory factor-1 is essential for natural killer cell function in vivo

The activation of natural killer (NK) cells, cytotoxic lymphocytes capable of major histocompatibility complex (MHC)-unrestricted killing and early antiviral defense, is temporally related to the increased interferon (IFN)-alpha/beta production that is seen in the viral infection of mice. Type I IFN...

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Veröffentlicht in:	The Journal of experimental medicine 1996-11, Vol.184 (5), p.2043-2048
Hauptverfasser:	Duncan, G S, Mittrücker, H W, Kägi, D, Matsuyama, T, Mak, T W
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens - analysis Antigens, Surface Cell Transplantation Cytotoxicity, Immunologic - drug effects DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism H-2 Antigens - immunology Interferon Regulatory Factor-1 Interferon-beta - pharmacology Interleukin-12 - pharmacology Interleukin-2 - pharmacology Killer Cells, Natural - immunology Lectins, C-Type Lymphocyte Activation Lymphocytic Choriomeningitis - immunology Mice Mice, Inbred C57BL Mice, Mutant Strains Neoplasms, Experimental - immunology NK Cell Lectin-Like Receptor Subfamily B Phosphoproteins - genetics Phosphoproteins - metabolism Proteins - analysis Transcription Factors - genetics Transcription Factors - metabolism
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