Function of the p55 tumor necrosis factor receptor "death domain" mediated by phosphatidylcholine-specific phospholipase C

Tumor necrosis factor (TNF) is a pleiotropic mediator of inflammation that has been implicated in the pathogenesis of devastating clinical syndromes including septic shock. We have investigated the role of a TNF-responsive phosphatidylcholine-specific phospholipase C (PC-PLC) for the cytotoxic and p...

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Veröffentlicht in:	The Journal of experimental medicine 1996-08, Vol.184 (2), p.725-733
Hauptverfasser:	Machleidt, T, Krämer, B, Adam, D, Neumann, B, Schütze, S, Wiegmann, K, Krönke, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, CD - physiology Bridged-Ring Compounds - pharmacology Cell Line Enterotoxins Enzyme Activation Mice Phosphatidylcholines - physiology Phosphodiesterase Inhibitors - pharmacology Phospholipases A - metabolism Receptors, Tumor Necrosis Factor - physiology Receptors, Tumor Necrosis Factor, Type I Shock, Septic - prevention & control Signal Transduction Thiones - pharmacology Type C Phospholipases - antagonists & inhibitors Type C Phospholipases - physiology
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