A critical role for transforming growth factor-beta but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45RB(low) CD4+ T cells
A T helper type 1 (Th1)-mediated colitis with similarities to inflammatory bowel disease in humans developed in severe combined immunodeficiency mice reconstituted with CD45RB(high) CD4+ splenic T cells and could be prevented by cotransfer of CD45RB(low) CD4+ T cells. Inhibition of this Th1 response...
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| Veröffentlicht in: | The Journal of experimental medicine 1996-06, Vol.183 (6), p.2669-2674 |
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| container_issue | 6 |
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| container_title | The Journal of experimental medicine |
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| creator | Powrie, F Carlino, J Leach, M W Mauze, S Coffman, R L |
| description | A T helper type 1 (Th1)-mediated colitis with similarities to inflammatory bowel disease in humans developed in severe combined immunodeficiency mice reconstituted with CD45RB(high) CD4+ splenic T cells and could be prevented by cotransfer of CD45RB(low) CD4+ T cells. Inhibition of this Th1 response by the CD45RB(low) T cell population could be reversed in vivo by an anti-transforming growth factor (TGF) beta antibody. Interleukin (IL) 4 was not required for either the differentiation of function of protective cells as CD45RB(low) CD4+ cells from IL-4-deficient mice were fully effective. These results identify a subpopulation of peripheral CD4+ cells and TGF-beta as critical components of the natural immune regulatory mechanism, which prevents the development of pathogenic Th1 responses in the gut, and suggests that this immunoregulatory population is distinct from Th2 cells. |
| doi_str_mv | 10.1084/jem.183.6.2669 |
| format | Article |
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Inhibition of this Th1 response by the CD45RB(low) T cell population could be reversed in vivo by an anti-transforming growth factor (TGF) beta antibody. Interleukin (IL) 4 was not required for either the differentiation of function of protective cells as CD45RB(low) CD4+ cells from IL-4-deficient mice were fully effective. 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Carlino, J ; Leach, M W ; Mauze, S ; Coffman, R L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c385t-38b240c6cdba70d7c0a4bf074381aa43e1c6d5bf18d88ce91fb433ee893a5c013</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>AIDS/HIV</topic><topic>Animals</topic><topic>Antibodies, Monoclonal - pharmacology</topic><topic>CD4-Positive T-Lymphocytes - immunology</topic><topic>Colitis - immunology</topic><topic>Colitis - pathology</topic><topic>Colitis - therapy</topic><topic>Flow Cytometry</topic><topic>Humans</topic><topic>Interleukin-4 - immunology</topic><topic>Interleukin-4 - physiology</topic><topic>Leukocyte Common Antigens</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Mice, Mutant Strains</topic><topic>Mice, SCID</topic><topic>Protein Tyrosine Phosphatase, Non-Receptor Type 1</topic><topic>Spleen - immunology</topic><topic>T-Lymphocytes - immunology</topic><topic>Th1 Cells - immunology</topic><topic>Transforming Growth Factor beta - immunology</topic><topic>Transforming Growth Factor beta - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Powrie, F</creatorcontrib><creatorcontrib>Carlino, J</creatorcontrib><creatorcontrib>Leach, M W</creatorcontrib><creatorcontrib>Mauze, S</creatorcontrib><creatorcontrib>Coffman, R L</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of experimental medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Powrie, F</au><au>Carlino, J</au><au>Leach, M W</au><au>Mauze, S</au><au>Coffman, R L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A critical role for transforming growth factor-beta but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45RB(low) CD4+ T cells</atitle><jtitle>The Journal of experimental medicine</jtitle><addtitle>J Exp Med</addtitle><date>1996-06-01</date><risdate>1996</risdate><volume>183</volume><issue>6</issue><spage>2669</spage><epage>2674</epage><pages>2669-2674</pages><issn>0022-1007</issn><eissn>1540-9538</eissn><abstract>A T helper type 1 (Th1)-mediated colitis with similarities to inflammatory bowel disease in humans developed in severe combined immunodeficiency mice reconstituted with CD45RB(high) CD4+ splenic T cells and could be prevented by cotransfer of CD45RB(low) CD4+ T cells. Inhibition of this Th1 response by the CD45RB(low) T cell population could be reversed in vivo by an anti-transforming growth factor (TGF) beta antibody. Interleukin (IL) 4 was not required for either the differentiation of function of protective cells as CD45RB(low) CD4+ cells from IL-4-deficient mice were fully effective. These results identify a subpopulation of peripheral CD4+ cells and TGF-beta as critical components of the natural immune regulatory mechanism, which prevents the development of pathogenic Th1 responses in the gut, and suggests that this immunoregulatory population is distinct from Th2 cells.</abstract><cop>United States</cop><pub>The Rockefeller University Press</pub><pmid>8676088</pmid><doi>10.1084/jem.183.6.2669</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0022-1007 |
| ispartof | The Journal of experimental medicine, 1996-06, Vol.183 (6), p.2669-2674 |
| issn | 0022-1007 1540-9538 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2192626 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | AIDS/HIV Animals Antibodies, Monoclonal - pharmacology CD4-Positive T-Lymphocytes - immunology Colitis - immunology Colitis - pathology Colitis - therapy Flow Cytometry Humans Interleukin-4 - immunology Interleukin-4 - physiology Leukocyte Common Antigens Mice Mice, Inbred BALB C Mice, Mutant Strains Mice, SCID Protein Tyrosine Phosphatase, Non-Receptor Type 1 Spleen - immunology T-Lymphocytes - immunology Th1 Cells - immunology Transforming Growth Factor beta - immunology Transforming Growth Factor beta - physiology |
| title | A critical role for transforming growth factor-beta but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45RB(low) CD4+ T cells |
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