Arginine at positions 13 or 70-71 in pocket 4 of HLA-DRB1 alleles is associated with susceptibility to tuberculoid leprosy

Evaluation of human histocompatibility leukocyte antigen (HLA) class II genes in 54 cases of tuberculoid leprosy (TL) and 44 controls has shown a positive association with HLA-DRB1 alleles that contain Arg13 or Arg70-Arg71. Among TL patients, 87% carry specific alleles of DRB1 Arg13 or Arg70-Arg71 a...

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Veröffentlicht in:	The Journal of experimental medicine 1996-03, Vol.183 (3), p.829-836
Hauptverfasser:	Zerva, L, Cizman, B, Mehra, N K, Alahari, S K, Murali, R, Zmijewski, C M, Kamoun, M, Monos, D S
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Amino Acid Sequence Arginine Chi-Square Distribution Crystallography, X-Ray Genes, MHC Class II Genetic Predisposition to Disease Histocompatibility Testing HLA-DR Antigens - chemistry HLA-DR Antigens - genetics HLA-DRB1 Chains Humans Leprosy, Tuberculoid - epidemiology Leprosy, Tuberculoid - genetics Leprosy, Tuberculoid - immunology Macromolecular Substances Models, Molecular Molecular Sequence Data Mycobacterium leprae Polymerase Chain Reaction Protein Conformation Reference Values Risk Factors
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