Interleukin 10 but not interleukin 4 is a natural suppressant of cutaneous inflammatory responses

We have examined the role of endogenously produced interleukin (IL) 4 and IL-10 in the regulation of inflammatory and immune reactions in the skin. In these experiments, irritant and contact hypersensitivity (CH) responses were elicited in mice with targeted disruptions of the IL-4 (IL-4T) or IL-10...

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Veröffentlicht in:	The Journal of experimental medicine 1995-07, Vol.182 (1), p.99-108
Hauptverfasser:	Berg, D J, Leach, M W, Kühn, R, Rajewsky, K, Müller, W, Davidson, N J, Rennick, D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - pharmacology CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - metabolism Croton Oil - toxicity Cytokines - biosynthesis Dermatitis, Allergic Contact - immunology Dermatitis, Allergic Contact - pathology Drug Eruptions - immunology Drug Eruptions - pathology Edema - chemically induced Interleukin-10 - genetics Interleukin-10 - physiology Interleukin-4 - genetics Interleukin-4 - physiology Irritants - toxicity Mice Mice, Inbred C57BL Mice, Knockout Necrosis Oxazolone - toxicity Tumor Necrosis Factor-alpha - antagonists & inhibitors Tumor Necrosis Factor-alpha - immunology Tumor Necrosis Factor-alpha - physiology
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