Identification and characterization of a 100-kD ligand for CD6 on human thymic epithelial cells

CD6 is a 130-kD glycoprotein expressed on the surface of thymocytes and peripheral blood T cells that is involved in TCR-mediated T cell activation. In thymus, CD6 mediates interactions between thymocytes and thymic epithelial (TE) cells. In indirect immunofluorescence assays, a recombinant CD6-immu...

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Veröffentlicht in:	The Journal of experimental medicine 1995-04, Vol.181 (4), p.1563-1568
Hauptverfasser:	Patel, D D, Wee, S F, Whichard, L P, Bowen, M A, Pesando, J M, Aruffo, A, Haynes, B F
Format:	Artikel
Sprache:	eng
Schlagworte:	Activated-Leukocyte Cell Adhesion Molecule Antibodies, Monoclonal - immunology Antigens, CD - metabolism Antigens, Differentiation, T-Lymphocyte - metabolism Antigens, Surface - immunology Child Epithelium - chemistry Epitopes - immunology Fibroblasts - chemistry Glycoproteins - chemistry Glycoproteins - immunology Glycoproteins - isolation & purification Glycoproteins - metabolism Humans Molecular Weight Organ Specificity Recombinant Fusion Proteins - metabolism Thymus Gland - chemistry Thymus Gland - cytology
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