Antifibrillarin autoantibodies present in systemic sclerosis and other connective tissue diseases interact with similar epitopes

Autoantibodies specific against fibrillarin, a 34-kD nucleolar protein associated with U3-snRNP, are present in patients with systemic sclerosis (SSc). To understand the mechanisms involved in the induction of these autoantibodies, we prepared a series of human fibrillarin recombinant proteins cover...

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Veröffentlicht in:	The Journal of experimental medicine 1995-03, Vol.181 (3), p.1027-1036
Hauptverfasser:	Kasturi, K N, Hatakeyama, A, Spiera, H, Bona, C A
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Antibody Specificity Autoantibodies - analysis Base Sequence Chromosomal Proteins, Non-Histone - biosynthesis Chromosomal Proteins, Non-Histone - immunology Connective Tissue Diseases - immunology Epitopes Fluorescent Antibody Technique Humans Molecular Sequence Data Radioimmunoassay Recombinant Proteins - biosynthesis Scleroderma, Systemic - immunology
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