Comparison of cell lines deficient in antigen presentation reveals a functional role for TAP-1 alone in antigen processing

Cytotoxic T lymphocytes (CTL) recognize antigenic peptides bound to major histocompatibility complex class I antigens on the cell surface of virus-infected cells. It is believed that the majority of peptides originate from cytoplasmic degradation of proteins assumed to be mediated by the "20S&q...

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Veröffentlicht in:	The Journal of experimental medicine 1994-10, Vol.180 (4), p.1415-1425
Hauptverfasser:	Gabathuler, R, Reid, G, Kolaitis, G, Driscoll, J, Jefferies, W A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigen Presentation ATP Binding Cassette Transporter, Subfamily B, Member 2 ATP-Binding Cassette Transporters - physiology beta 2-Microglobulin - analysis Biological Transport Cell Line Interferon-gamma - pharmacology Mice Mice, Inbred C57BL T-Lymphocytes, Cytotoxic - immunology
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