Lysis of ovarian cancer cells by human lymphocytes redirected with a chimeric gene composed of an antibody variable region and the Fc receptor gamma chain

To expand the spectrum of recognition of effector lymphocytes and to redirect them towards predefined targets, we have altered the specificity of human tumor-infiltrating lymphocytes (TIL) through stable modification with chimeric receptor genes consisting of single-chain antibody variable regions l...

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Veröffentlicht in:	The Journal of experimental medicine 1993-07, Vol.178 (1), p.361-366
Hauptverfasser:	Hwu, P, Shafer, G E, Treisman, J, Schindler, D G, Gross, G, Cowherd, R, Rosenberg, S A, Eshhar, Z
Format:	Artikel
Sprache:	eng
Schlagworte:	Cloning, Molecular Cytotoxicity, Immunologic Female Granulocyte-Macrophage Colony-Stimulating Factor - biosynthesis Humans Immunoglobulin Variable Region - genetics Immunotherapy, Adoptive Lymphocytes, Tumor-Infiltrating - immunology Ovarian Neoplasms - immunology Ovarian Neoplasms - therapy Receptors, IgG - genetics Recombinant Fusion Proteins - genetics Transfection
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