Antibodies to intercellular adhesion molecule 1/lymphocyte function-associated antigen 1 prevent crescent formation in rat autoimmune glomerulonephritis

In patients with glomerulonephritis widespread crescents are associated with a poor prognosis. Crescent formation appears to depend on the migration of mononuclear cells into Bowman's space, and therefore the interaction between leukocytes and glomerular endothelium may be a critical event in t...

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Veröffentlicht in:	The Journal of experimental medicine 1993-03, Vol.177 (3), p.667-677
Hauptverfasser:	NISHIKAWA, K, GUO, Y.-J, MIYASAKA, M, TAMATANI, T, COLLINS, A. B, SY, M.-S, MCCLUSKEY, R. T, ANDRES, G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - immunology Antibodies, Monoclonal - pharmacology Autoimmune Diseases - pathology Autoimmune Diseases - physiopathology Autoimmune Diseases - prevention & control Basement Membrane - immunology Basement Membrane - pathology Biological and medical sciences Cell Adhesion Molecules - analysis Cell Adhesion Molecules - immunology Cell Adhesion Molecules - metabolism Endothelium - chemistry Endothelium - immunology Endothelium - pathology Fluorescent Antibody Technique Glomerulonephritis Glomerulonephritis - pathology Glomerulonephritis - physiopathology Glomerulonephritis - prevention & control Immunoglobulin G - analysis Immunoglobulin G - metabolism Immunohistochemistry Intercellular Adhesion Molecule-1 Kidney Glomerulus - chemistry Kidney Glomerulus - immunology Kidney Glomerulus - pathology Leukocytes - chemistry Leukocytes - immunology Leukocytes - pathology Lymphocyte Function-Associated Antigen-1 - analysis Lymphocyte Function-Associated Antigen-1 - immunology Lymphocyte Function-Associated Antigen-1 - metabolism Macrophages - immunology Macrophages - pathology Medical sciences Nephrology. Urinary tract diseases Nephropathies. Renovascular diseases. Renal failure Rats Rats, Inbred WKY T-Lymphocytes - immunology T-Lymphocytes - pathology
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