Surface expression of alpha 4 integrin by CD4 T cells is required for their entry into brain parenchyma

Cloned CD4 T cell lines that recognize the Ac1-16 peptide of myelin basic protein bound to I-Au were isolated and used to analyze the immunopathogenesis of experimental autoimmune encephalomyelitis (EAE). T helper type 1 (Th1) clones induced disease, while Th2 clones did not. Using variants of a sin...

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Veröffentlicht in:	The Journal of experimental medicine 1993-01, Vol.177 (1), p.57-68
Hauptverfasser:	Baron, J L, Madri, J A, Ruddle, N H, Hashim, G, Janeway, Jr, C A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - immunology Brain - immunology CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - physiology Cell Adhesion Molecules - physiology Cell Movement Clone Cells Encephalomyelitis, Autoimmune, Experimental - etiology Intercellular Adhesion Molecule-1 Mice Mice, Inbred BALB C Myelin Basic Protein - immunology Receptors, Very Late Antigen - analysis Receptors, Very Late Antigen - physiology Vascular Cell Adhesion Molecule-1
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