Induction of autoreactive B cells allows priming of autoreactive T cells

A novel mechanism for breaking T cell self tolerance is described. B cells induced to make autoantibody by immunization of mice with the non-self protein human cytochrome c can present the self protein mouse cytochrome c to autoreactive T cells in immunogenic form. This mechanism of breaking T cell...

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Veröffentlicht in:	The Journal of experimental medicine 1991-06, Vol.173 (6), p.1433-1439
Hauptverfasser:	RONG-HWA LIN, MAMULA, M. J, HARDIN, J. A, JANEWAY, C. A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibody Formation Antigen-Presenting Cells - immunology Autoimmunity - immunology B-Lymphocytes - immunology Biological and medical sciences Cytochrome c Group - immunology Fundamental and applied biological sciences. Psychology Fundamental immunology Histocompatibility Antigens Class II - immunology Immune Tolerance Immunobiology Immunological tolerance Lymphocyte Activation Mice Mice, Inbred Strains T-Lymphocytes - immunology
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