DNA damage, cellular senescence and organismal ageing: causal or correlative

Cellular senescence has long been used as a cellular model for understanding mechanisms underlying the ageing process. Compelling evidence obtained in recent years demonstrate that DNA damage is a common mediator for both replicative senescence, which is triggered by telomere shortening, and prematu...

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Veröffentlicht in:	Nucleic acids research 2007-12, Vol.35 (22), p.7417-7428
Hauptverfasser:	Chen, Jian-Hua, Hales, C. Nicholes, Ozanne, Susan E
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - genetics Animals Cellular Senescence - genetics DNA Damage DNA, Mitochondrial - metabolism Humans Survey and Summary
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