Self-renewal of human embryonic stem cells requires insulin-like growth factor-1 receptor and ERBB2 receptor signaling

Despite progress in developing defined conditions for human embryonic stem cell (hESC) cultures, little is known about the cell-surface receptors that are activated under conditions supportive of hESC self-renewal. A simultaneous interrogation of 42 receptor tyrosine kinases (RTKs) in hESCs followin...

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Veröffentlicht in:	Blood 2007-12, Vol.110 (12), p.4111-4119
Hauptverfasser:	Wang, Linlin, Schulz, Thomas C., Sherrer, Eric S., Dauphin, Derek S., Shin, Soojung, Nelson, Angelique M., Ware, Carol B., Zhan, Mei, Song, Chao-Zhong, Chen, Xiaoji, Brimble, Sandii N., McLean, Amanda, Galeano, Maria J., Uhl, Elizabeth W., D'Amour, Kevin A., Chesnut, Jonathan D., Rao, Mahendra S., Blau, C. Anthony, Robins, Allan J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - pharmacology Apoptosis - drug effects Apoptosis - physiology Benzothiazoles - pharmacology Biological and medical sciences Cell Differentiation - drug effects Cell Differentiation - physiology Cell Line Cell Proliferation - drug effects Culture Media, Conditioned Embryonic Stem Cells - cytology Embryonic Stem Cells - metabolism Fibroblast Growth Factor 2 - pharmacology Fibroblasts - cytology Fibroblasts - metabolism Hematologic and hematopoietic diseases Humans Medical sciences Mice Neuregulin-1 - pharmacology Phosphorylation - drug effects Pluripotent Stem Cells - cytology Pluripotent Stem Cells - metabolism Receptor, ErbB-2 - antagonists & inhibitors Receptor, ErbB-2 - metabolism Receptor, ErbB-3 - antagonists & inhibitors Receptor, ErbB-3 - metabolism Receptor, IGF Type 2 - antagonists & inhibitors Receptor, IGF Type 2 - metabolism Receptor, Insulin - antagonists & inhibitors Receptor, Insulin - metabolism Signal Transduction - drug effects Signal Transduction - physiology Stem Cells in Hematology Tyrphostins - pharmacology
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